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Electrochemical Sensor Based on Multi-Walled Carbon Nanotubes and N-Doped TiO2 Nanoparticles for Voltametric Simultaneous Determination of Benserazide and Levodopa.
da Silva, Elisangela Pacheco; Araujo, Mayara da Silva; Kunita, Marcos H; Matos, Roberto; Medeiros, Roberta Antigo.
Afiliação
  • da Silva EP; Department of Chemistry, State University of Maringá, Maringá 87020-900, PR, Brazil.
  • Araujo MDS; Department of Chemistry, State University of Londrina, Londrina 86057-970, PR, Brazil.
  • Kunita MH; Department of Chemistry, State University of Maringá, Maringá 87020-900, PR, Brazil.
  • Matos R; Department of Chemistry, State University of Londrina, Londrina 86057-970, PR, Brazil.
  • Medeiros RA; Department of Chemistry, State University of Londrina, Londrina 86057-970, PR, Brazil.
Molecules ; 27(23)2022 Dec 06.
Article em En | MEDLINE | ID: mdl-36500705
An electrochemical sensor for simultaneous determination of Benserazide (BEZ) and levodopa (L-dopa) was successfully developed using a glassy carbon electrode (GCE) modified with multi-walled carbon nanotube and nitrogen-doped titanium dioxide nanoparticles (GCE/MWCNT/N-TiO2). Cyclic voltammetry and square wave voltammetry were employed to investigate the electrochemical behavior of different working electrodes and analytes. In comparison with unmodified GCE, the modified electrode exhibited better electrocatalytic activity towards BEZ and L-dopa and was efficient in providing a satisfactory separation for oxidation peaks, with a potential difference of 140 mV clearly allows the simultaneous determination of these compounds. Under the optimized conditions, linear ranges of 2.0-20.0 and 2.0-70.0 µmol L-1 were obtained for BEZ and L-dopa, respectively, with a limit of detection of 1.6 µmol L-1 for BEZ and 2.0 µmol L-1 for L-dopa. The method was applied in simultaneous determination of the analytes in pharmaceutical samples, and the accuracy was attested by comparison with HPLC-DAD as the reference method, with a relative error lower than 4.0%.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanotubos de Carbono Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanotubos de Carbono Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça