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The acute phase response in bats (Carollia perspicillata) varies with time and dose of the immune challenge.
Viola, Matheus F; Gerardo Herrera M, L; da Cruz-Neto, Ariovaldo P.
Afiliação
  • Viola MF; Laboratório de Fisiologia Animal (LaFA), Departamento de Biodiversidade, Instituto de Biociências, Universidade Estadual Paulista Júlio de Mesquita Filho, 13506-900 Rio Claro, São Paulo, Brazil.
  • Gerardo Herrera M L; Estación de Biología Chamela, Instituto de Biología, Universidad Nacional, Autónoma de México, 48980 San Patricio, Jalisco, México.
  • da Cruz-Neto AP; Laboratório de Fisiologia Animal (LaFA), Departamento de Biodiversidade, Instituto de Biociências, Universidade Estadual Paulista Júlio de Mesquita Filho, 13506-900 Rio Claro, São Paulo, Brazil.
J Exp Biol ; 225(24)2022 12 15.
Article em En | MEDLINE | ID: mdl-36448935
The acute phase response (APR) is a core component of the innate immune response and represents the first line of immune defense used in response to infections. Although several studies with vertebrates reported fever, a decrease in food intake and body mass, and an increase in neutrophil/lymphocyte ratio and total white blood cell count after lipopolysaccharide (LPS) inoculation, there was great variability in the magnitude of these responses. Some of these differences might reflect, to some extent, differences in the time of endotoxin inoculation (during active or rest periods) and dose. Therefore, our study tested the interplay between LPS dose and time of injection on selected physiological (fever and increase in total white blood cell count and neutrophil/lymphocyte ratio) and behavioral (food intake) components of the APR using a Neotropical fruit-eating bat (Carollia perspicillata) as a model organism. We predicted that LPS would trigger a dose- and time-dependent response in APR components. APR components were assessed in rest and active periods after injection of three doses of LPS (5, 10 and 15 mg kg-1 LPS). The results indicate a more robust decrease in food intake at higher doses during the active period, while increased neutrophil/lymphocyte ratio was more robust during the active period regardless of dose. Furthermore, the skin temperature increase lasted longer at higher doses regardless of the timing of injections. Our study offers important insights into the dependence of time as well as the LPS dosage effect in the APR of bats, and how they deal with the magnitude of infections at different times of day.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quirópteros / Reação de Fase Aguda Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Exp Biol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quirópteros / Reação de Fase Aguda Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Exp Biol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido