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Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models.
Song, Ke; Yang, Xinyan; An, Geng; Xia, Xinyu; Zhao, Jiexiang; Xu, Xiaoheng; Wan, Cong; Liu, Tianyuan; Zheng, Yi; Ren, Shaofang; Wang, Mei; Chang, Gang; Cronin, Shane J F; Penninger, Josef M; Jing, Tao; Ou, Xianghong; Rao, Shuan; Liu, Zhaoting; Zhao, Xiao-Yang.
Afiliação
  • Song K; State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Yang X; State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • An G; Reproductive Medicine Center of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
  • Xia X; State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Zhao J; State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Xu X; State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Wan C; State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Liu T; Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
  • Zheng Y; State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Ren S; State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Wang M; State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Chang G; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Biochemistry and Molecular Biology, Shenzhen University Health Science Center, Shenzhen, Guangdong, China.
  • Cronin SJF; IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
  • Penninger JM; IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
  • Jing T; Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
  • Ou X; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China.
  • Rao S; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China.
  • Liu Z; Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China. raoshuan1@smu.edu.cn.
  • Zhao XY; State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China. liuzhaoting@i.smu.edu.cn.
Nat Commun ; 13(1): 7335, 2022 11 28.
Article em En | MEDLINE | ID: mdl-36443325
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Barreira Hematotesticular / Diabetes Mellitus Tipo 2 Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Barreira Hematotesticular / Diabetes Mellitus Tipo 2 Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido