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Rotary Jet Spinning (RJS): A Key Process to Produce Biopolymeric Wound Dressings.
Bahú, Juliana O; Melo de Andrade, Lucas R; Crivellin, Sara; Khouri, Nadia G; Sousa, Sara O; Fernandes, Luiza M I; Souza, Samuel D A; Concha, Luz S Cárdenas; Schiavon, Maria I R B; Benites, Cibelem I; Severino, Patrícia; Souto, Eliana B; Concha, Viktor O Cárdenas.
Afiliação
  • Bahú JO; INCT-BIOFABRIS, School of Chemical Engineering, University of Campinas, Albert Einstein Ave., Cidade Universitária Zeferino Vaz, nº. 500, Campinas 13083-852, São Paulo, Brazil.
  • Melo de Andrade LR; Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Mato Grosso do Sul, Brazil.
  • Crivellin S; INCT-BIOFABRIS, School of Chemical Engineering, University of Campinas, Albert Einstein Ave., Cidade Universitária Zeferino Vaz, nº. 500, Campinas 13083-852, São Paulo, Brazil.
  • Khouri NG; INCT-BIOFABRIS, School of Chemical Engineering, University of Campinas, Albert Einstein Ave., Cidade Universitária Zeferino Vaz, nº. 500, Campinas 13083-852, São Paulo, Brazil.
  • Sousa SO; Institute of Environmental, Chemical and Pharmaceutical Science, School of Chemical Engineering, Federal University of São Paulo (UNIFESP), São Nicolau St., Jd. Pitangueiras, Diadema 09913-030, São Paulo, Brazil.
  • Fernandes LMI; Institute of Environmental, Chemical and Pharmaceutical Science, School of Chemical Engineering, Federal University of São Paulo (UNIFESP), São Nicolau St., Jd. Pitangueiras, Diadema 09913-030, São Paulo, Brazil.
  • Souza SDA; INCT-BIOFABRIS, School of Chemical Engineering, University of Campinas, Albert Einstein Ave., Cidade Universitária Zeferino Vaz, nº. 500, Campinas 13083-852, São Paulo, Brazil.
  • Concha LSC; Graduate School, Sciences and Engineering, National University of Trujillo, Av. Juan Pablo II S/N Urb. San Andrés, Trujillo 13011, La Libertad, Peru.
  • Schiavon MIRB; INCT-BIOFABRIS, School of Chemical Engineering, University of Campinas, Albert Einstein Ave., Cidade Universitária Zeferino Vaz, nº. 500, Campinas 13083-852, São Paulo, Brazil.
  • Benites CI; Federal Laboratory of Agricultural and Livestock Defense (LFDA-SP), Ministry of Agriculture, Livestock and Food Supply (MAPA), Campinas 70043-900, São Paulo, Brazil.
  • Severino P; Technology and Research Institute (ITP), Tiradentes University (UNIT), Murilo Dantas Ave., Farolândia, nº 300, Aracaju 49032-490, Sergipe, Brazil.
  • Souto EB; Department of Pharmaceutical Technology, Faculty of Pharmacy of University of Porto (FFUP), Rua Jorge de Viterbo Ferreira, nº 228, 4050-313 Porto, Portugal.
  • Concha VOC; REQUIMTE/UCIBIO, Faculty of Pharmacy, University of Porto, de Jorge Viterbo Ferreira, nº. 228, 4050-313 Porto, Portugal.
Pharmaceutics ; 14(11)2022 Nov 18.
Article em En | MEDLINE | ID: mdl-36432691
Wounds result from different causes (e.g., trauma, surgeries, and diabetic ulcers), requiring even extended periods of intensive care for healing, according to the patient's organism and treatment. Currently, wound dressings generated by polymeric fibers at micro and nanometric scales are promising for healing the injured area. They offer great surface area and porosity, mimicking the fibrous extracellular matrix structure, facilitating cell adhesion, migration, and proliferation, and accelerating the wound healing process. Such properties resulted in countless applications of these materials in biomedical and tissue engineering, also as drug delivery systems for bioactive molecules to help tissue regeneration. The techniques used to engineer these fibers include spinning methods (electro-, rotary jet-), airbrushing, and 3D printing. These techniques have important advantages, such as easy-handle procedure and process parameters variability (type of polymer), but encounter some scalability problems. RJS is described as a simple and low-cost technique resulting in high efficiency and yield for fiber production, also capable of bioactive agents' incorporation to improve the healing potential of RJS wound dressings. This review addresses the use of RJS to produce polymeric fibers, describing the concept, type of configuration, comparison to other spinning techniques, most commonly used polymers, and the relevant parameters that influence the manufacture of the fibers, for the ultimate use in the development of wound dressings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceutics Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceutics Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça