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Body Weight, Central Adiposity, and Fasting Hyperglycemia Are Associated with Tumor Characteristics in a Brazilian Cohort of Women with Breast Cancer.
Gioseffi, Clara; Padilha, Patricia de Carvalho; Chaves, Gabriela Villaça; Oliveira, Livia Costa de; Peres, Wilza Arantes Ferreira.
Afiliação
  • Gioseffi C; José Alencar Gomes da Silva National Cancer Institute (INCA), Rio de Janeiro 20560-120, Brazil.
  • Padilha PC; Department of Nutrition and Dietetics, Josué de Castro Nutrition Institute, Health Science Center, Campus Fundão, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
  • Chaves GV; José Alencar Gomes da Silva National Cancer Institute (INCA), Rio de Janeiro 20560-120, Brazil.
  • Oliveira LC; José Alencar Gomes da Silva National Cancer Institute (INCA), Rio de Janeiro 20560-120, Brazil.
  • Peres WAF; Department of Nutrition and Dietetics, Josué de Castro Nutrition Institute, Health Science Center, Campus Fundão, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Nutrients ; 14(22)2022 Nov 21.
Article em En | MEDLINE | ID: mdl-36432611
The aim of this study was to evaluate the association of overweight, obesity, excess central adiposity, hyperglycemia, and diabetes mellitus with tumor characteristics in breast cancer. In this retrospective cohort study that enrolled 2127 women with breast cancer, the independent variables collected were fasting blood glucose, body mass index, central adiposity (waist circumference and waist-to-hip circumference ratio (WHR)), and waist-to-height ratio. The tumor characteristics (infiltrating, ductal grade, hormone receptor-positive (HR+), human epidermal growth factor receptor, triple negative, size, lymph node involvement, and clinical stage) were the dependent variables. Most of the women were postmenopausal (73.5%), with an infiltrating tumor (83.0%), HR+ (82.0%), and overweight or obese (71.0%). For the premenopausal women, obesity was associated with grade 3 ductal tumor (odds ratio (OR): 1.70; 95% confidence interval (95% CI): 1.09-2.66), triple negative (OR: 1.37, 95% CI: 1.08-3.24), and size ≥ 2 cm (OR: 2.20, 95% CI: 1.36-3.56). For the postmenopausal women, obesity was associated with WHR, infiltrating tumor (OR: 1.73, 95% CI: 1.56-1.95), size ≥ 2 cm (OR: 1.38, 95% CI: 1.11-1.71), lymph node involvement (OR: 1.24, 95% CI: 1.02-1.56), and stages III-IV (OR: 1.76, 95% CI: 1.30-2.65). Excess body weight and central adiposity were associated with tumor aggressiveness characteristics in women with breast cancer, confirming the importance of nutritional status.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Hiperglicemia Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Nutrients Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Hiperglicemia Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Nutrients Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça