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Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives.
Silva-Aguiar, Rodrigo P; Teixeira, Douglas E; Peres, Rodrigo A S; Peruchetti, Diogo B; Gomes, Carlos P; Schmaier, Alvin H; Rocco, Patricia R M; Pinheiro, Ana Acacia S; Caruso-Neves, Celso.
Afiliação
  • Silva-Aguiar RP; Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
  • Teixeira DE; Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
  • Peres RAS; Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
  • Peruchetti DB; Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
  • Gomes CP; Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
  • Schmaier AH; School of Medicine and Surgery, Federal University of the State of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
  • Rocco PRM; Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Pinheiro AAS; University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
  • Caruso-Neves C; Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
Int J Mol Sci ; 23(22)2022 Nov 17.
Article em En | MEDLINE | ID: mdl-36430671
Since the outbreak of COVID-19 disease, a bidirectional interaction between kidney disease and the progression of COVID-19 has been demonstrated. Kidney disease is an independent risk factor for mortality of patients with COVID-19 as well as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leading to the development of acute kidney injury (AKI) and chronic kidney disease (CKD) in patients with COVID-19. However, the detection of kidney damage in patients with COVID-19 may not occur until an advanced stage based on the current clinical blood and urinary examinations. Some studies have pointed out the development of subclinical acute kidney injury (subAKI) syndrome with COVID-19. This syndrome is characterized by significant tubule interstitial injury without changes in the estimated glomerular filtration rate. Despite the complexity of the mechanism(s) underlying the development of subAKI, the involvement of changes in the protein endocytosis machinery in proximal tubule (PT) epithelial cells (PTECs) has been proposed. This paper focuses on the data relating to subAKI and COVID-19 and the role of PTECs and their protein endocytosis machinery in its pathogenesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Insuficiência Renal Crônica / Injúria Renal Aguda / COVID-19 Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Insuficiência Renal Crônica / Injúria Renal Aguda / COVID-19 Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça