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First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil.
de Oliveira, Rômulo Vieira Mello; Corrêa-Moreira, Danielly; Mendes, Túlio Vieira; da Costa, Gisela Lara; Vieira, Renata de Magalhães; Buchele, Cynthia Miranda Nascimento; Lins, Rodrigo Schrage; Ferreira, Ana Beatriz Teixeira Brandão Camello; Veira, Daniela Barbosa; Pedroso, Rafael Santos de Aragão; de Faria, Vinícius Tadeu Dias Pereira; Oliveira, Manoel Marques Evangelista.
Afiliação
  • de Oliveira RVM; Infectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, Brazil.
  • Corrêa-Moreira D; Evandro Chagas National Institute of Infectious Diseases, Rio de Janeiro, Brazil; Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi, Oswaldo Cruz Institute, Rio de Janeiro, Brazil.
  • Mendes TV; Infectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, Brazil; Evandro Chagas National Institute of Infectious Diseases, Rio de Janeiro, Brazil.
  • da Costa GL; Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi, Oswaldo Cruz Institute, Rio de Janeiro, Brazil.
  • Vieira RM; Infectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, Brazil.
  • Buchele CMN; Infectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, Brazil.
  • Lins RS; Infectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, Brazil.
  • Ferreira ABTBC; Infectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, Brazil.
  • Veira DB; Infectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, Brazil.
  • Pedroso RSA; Infectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, Brazil.
  • de Faria VTDP; Infectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, Brazil.
  • Oliveira MME; Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi, Oswaldo Cruz Institute, Rio de Janeiro, Brazil. Electronic address: manoel.marques@ioc.fiocruz.br.
Int J Infect Dis ; 126: 94-97, 2023 Jan.
Article em En | MEDLINE | ID: mdl-36427702
INTRODUCTION: Fungal infections of the central nervous system present a variety of clinical syndromes, such as meningitis, encephalitis, raised intracranial pressure with a nonspecific presentation, and, in the last two decades, have increased the incidence of these fungal infections. Fungal meningoencephalitis is frequently associated with Cryptococcus, but this report stands out for presenting one species of Penicillium genus. OBJECTIVES: Here, we present the first case of meningoencephalitis associated with brain injury caused by Penicillium chrysogenum, in a patient who is immunocompetent and was admitted to Hospital Naval Marcílio Dias, Rio de Janeiro, Brazil. METHODS: To identify the fungal species, we performed phenotypic and genotypic methodologies, from the culture to the sequencing of internal transcribed spacer region, and ß-tubulin gene, a rare fungus in cerebrospinal fluid cultures, belonging to the genus Penicillium, was identified. CONCLUSION: We highlight the importance of the first report of meningoencephalitis caused by P. chrysogenum in a patient who is immunocompetent, registered in Brazil. We also emphasize the need for further studies to determine an effective treatment with the least possible side effects for patients infected by fungi that are rarely related to the most severe forms of invasive infections.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium / Penicillium chrysogenum / Meningite / Meningoencefalite / Micoses Tipo de estudo: Prognostic_studies Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium / Penicillium chrysogenum / Meningite / Meningoencefalite / Micoses Tipo de estudo: Prognostic_studies Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá