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The Barretos Cancer Hospital Animal Facility: Implementation and Results of a Dedicated Platform for Preclinical Oncology Models.
Teixeira, Silvia A; Luzzi, Mayara de Cassia; Martin, Ana Carolina Baptista Moreno; Duarte, Terence Teixeira; Leal, Mônica de Oliveira; Teixeira, Gustavo Ramos; Reis, Monise Tadin; Junior, Carlos Roberto Almeida; Santos, Karina; Melendez, Matias Eliseo; Silva, Diego da Cunha Silveira Alves da; Bernécule, Priscila Neves; Firmino, Higor Vinicius Lourenço; Alves, Ana Laura Vieira; Guimarães, Denise Peixoto; Borduqui, João Vitor; Laus, Ana Carolina; Mançano, Bruna Minniti; Reis, Rui Manuel.
Afiliação
  • Teixeira SA; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
  • Luzzi MC; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
  • Martin ACBM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
  • Duarte TT; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
  • Leal MO; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
  • Teixeira GR; Department of Pathology, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
  • Reis MT; Barretos School of Health Sciences, Dr. Paulo Prata-FACISB, Barretos 14785-002, São Paulo, Brazil.
  • Junior CRA; Department of Pathology, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
  • Santos K; Department of Neurosurgery, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
  • Melendez ME; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
  • Silva DDCSAD; Department of Radiology, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
  • Bernécule PN; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
  • Firmino HVL; Molecular Carcinogenesis Program, National Cancer Institute, Rio de Janeiro 20231-050, Brazil.
  • Alves ALV; Department of Radiology, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
  • Guimarães DP; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
  • Borduqui JV; Barretos School of Health Sciences, Dr. Paulo Prata-FACISB, Barretos 14785-002, São Paulo, Brazil.
  • Laus AC; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
  • Mançano BM; Barretos School of Health Sciences, Dr. Paulo Prata-FACISB, Barretos 14785-002, São Paulo, Brazil.
  • Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil.
Vet Sci ; 9(11)2022 Nov 16.
Article em En | MEDLINE | ID: mdl-36423085
The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and ApcMin mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Vet Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Vet Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça