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Identification of bioactive compounds and cytogenotoxicity of the essential oil from the leaves of Croton heliotropiifolius Kunth.
Lopes, Katianne Soares; Sousa, Herbert Gonzaga; Artur E Silva Filho, Francisco; da Silva Neta, Enedina Rodrigues; de Lima, Sidney Gonçalo; Dos Santos Rocha, Márcio; Marques, Rosemarie Brandim; da Costa, Charllyton Luis Sena; de Oliveira, André Nunes; Bezerra, Dayla Geovana Pereira; Alline Martins, Francielle; de Almeida, Pedro Marcos; Uchôa, Valdiléia Teixeira; Martins Maia Filho, Antônio Luiz.
Afiliação
  • Lopes KS; Graduate Program in Chemistry/PPGQ-GERATEC-DQ - State University of Piauí, Teresina, Brazil.
  • Sousa HG; Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Brazil.
  • Artur E Silva Filho F; State University of Piauí, Campus Alexandre Alves Oliveira, Parnaíba, Brazil.
  • da Silva Neta ER; Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Brazil.
  • de Lima SG; Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Brazil.
  • Dos Santos Rocha M; Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Brazil.
  • Marques RB; Graduate Program in Chemistry/PPGQ-GERATEC-DQ - State University of Piauí, Teresina, Brazil.
  • da Costa CLS; Research Center in Biotechnology and Biodiversity - State University of Piauí, Teresina, Brazil.
  • de Oliveira AN; Research Center in Biotechnology and Biodiversity - State University of Piauí, Teresina, Brazil.
  • Bezerra DGP; Research Center in Biotechnology and Biodiversity - State University of Piauí, Teresina, Brazil.
  • Alline Martins F; Research Center in Biotechnology and Biodiversity - State University of Piauí, Teresina, Brazil.
  • de Almeida PM; Graduate Program in Chemistry/PPGQ-GERATEC-DQ - State University of Piauí, Teresina, Brazil.
  • Uchôa VT; Graduate Program in Chemistry/PPGQ-GERATEC-DQ - State University of Piauí, Teresina, Brazil.
  • Martins Maia Filho AL; Research Center in Biotechnology and Biodiversity - State University of Piauí, Teresina, Brazil.
J Toxicol Environ Health A ; 85(24): 1002-1018, 2022 12 17.
Article em En | MEDLINE | ID: mdl-36415179
Croton heliotropiifolius Kunth, popularly known as "quince" and "velame," contains a high concentration of volatile oils in the leaves, and widely used in folk medicine as an antiseptic, analgesic, sedative, anti-inflammatory, spasmolytic and local anesthetic. The objectives of this investigation were to (1) identify the phytochemical compounds and (2) assess the cytogenotoxicity of the essential oil extracted from the leaves of C. heliotropiifolius Kunth. The oil was extracted utilizing hydrodistillation and phytochemical profile determined using gas chromatography and mass spectrometry (GCMS). In the toxicogenetics analysis, Allium cepa roots were exposed to 1% dimethylsulfoxide or methylmethanesulfonate (MMS, 10 µg/ml) negative and positive controls, respectively, and to C. heliotropiifolius oil at 6 concentrations (0.32; 1.6; 8; 40; 200 or 1000 µg/ml). The phytochemical profile exhibited 40 chromatographic bands, and 33 compounds identified. α-pinene (16.7%) and 1,8-cineole (13.81%) were identified as the major compounds. Some of these identified secondary metabolites displayed biological and pharmacological activities previously reported including antiseptic, analgesic, sedative, anti-inflammatory as well insecticidal, antiviral, anti-fungal actions. In the A. cepa test, C. heliotropiifolius leaves oil induced cytotoxicity at concentrations of 0.32, 1.6 or 200 µg/ml and genotoxicity at 200 or 1000 µg/ml as evidenced by increased presence of micronuclei and significant chromosomal losses. Based upon our observations data demonstrated that the essential oil of C. heliotropiifolius leaves contain monoterpene hydrocarbons, and oxygenated monoterpenes, sesquiterpenes, and oxygenated sesquiterpenes which are associated with cytotoxic and genotoxic responses noted in on A. cepa cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos Voláteis / Croton / Anti-Infecciosos Locais Tipo de estudo: Diagnostic_studies Idioma: En Revista: J Toxicol Environ Health A Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos Voláteis / Croton / Anti-Infecciosos Locais Tipo de estudo: Diagnostic_studies Idioma: En Revista: J Toxicol Environ Health A Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido