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Severe maternal morbidity and mortality during the COVID-19 pandemic: a cohort study in Rio de Janeiro.
Brendolin, Michelle; Fuller, Trevon; Wakimoto, Mayumi; Rangel, Larissa; Rodrigues, Gustavo Mourão; Rohloff, Roger D; Guaraldo, Lusiele; Nielsen-Saines, Karin; Brasil, Patrícia.
Afiliação
  • Brendolin M; Acute Febrile Illnesses Department, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Fuller T; Maternity Department, Adão Pereira Nunes Hospital, Duque de Caxias, Brazil.
  • Wakimoto M; Acute Febrile Illnesses Department, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Rangel L; Pediatric Infectious Diseases Division, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
  • Rodrigues GM; Acute Febrile Illnesses Department, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Rohloff RD; Acute Febrile Illnesses Department, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Guaraldo L; Maternity Department, Adão Pereira Nunes Hospital, Duque de Caxias, Brazil.
  • Nielsen-Saines K; Perinatal de Laranjeiras Maternity Hospital, Rio de Janeiro, Brazil.
  • Brasil P; Acute Febrile Illnesses Department, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
IJID Reg ; 6: 1-6, 2023 Mar.
Article em En | MEDLINE | ID: mdl-36407853
Objectives: To identify factors associated with adverse maternal outcomes during the coronavirus disease 2019 (COVID-19) pandemic. Methods: This was a single-centre prospective cohort study at a maternity department in a public general hospital in Rio de Janeiro. All pregnant women evaluated for emergency care, labour and delivery, respiratory symptoms, obstetric reasons or medical reasons between May 2020 and March 2022 at the study institution were invited to enrol in this study. The endpoint was maternal mortality or intensive care unit (ICU) admission. Results: In total, 1609 pregnant women were enrolled in this study. Of these, 25.5% (n=410) were infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) based on reverse transcription polymerase chain reaction or an antigen test. There were 21 deaths and 67 ICU admissions in 4% of the cohort. The incidence of severe maternal morbidity and mortality was higher during the Gamma wave than during the Delta wave (P=0.003). Vaccination conferred protection against the endpoint [relative risk (RR) 0.4, 95% confidence interval (CI) 0.1-0.9; P=0.0169]. Factors associated with severe morbidity and mortality included caesarean section (RR 3.7, 95% CI 1.7-7.9; P=0.0008), SARS-CoV-2 infection in the third trimester (RR 2.4, 95% CI 1.1-5.6; P=0.0006) and comorbidities (RR 3, 95% CI 1.8-5.2; P<0.0001). Conclusions: COVID-19 was significantly associated with the risk of severe maternal morbidity and mortality. Immunization of pregnant women against COVID-19 was highly protective against adverse outcomes, and should be encouraged during pregnancy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: IJID Reg Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: IJID Reg Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido