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No Association Between Interleukin 6 and Inducible Nitric Oxide Synthase Polymorphisms and Dengue Infection: A Case-Control Study.
Dos Santos, Barbara Rayssa Correia; Melo Dos Santos, Ana Caroline; Magalhaes Bastos, Dhayane; Silva Santos, Leandro Douglas; de Souza Praxedes, Francyane Adielle; Sathio Bessoni Tanabe, Ithallo; Fireman de Farias, Karol; Martins de Souza Figueiredo, Elaine Virginia.
Afiliação
  • Dos Santos BRC; Molecular Biology and Gene Expression Laboratory (LABMEG), Federal University of Alagoas, Arapiraca, Brazil.
  • Melo Dos Santos AC; Molecular Biology and Gene Expression Laboratory (LABMEG), Federal University of Alagoas, Arapiraca, Brazil.
  • Magalhaes Bastos D; Molecular Biology and Gene Expression Laboratory (LABMEG), Federal University of Alagoas, Arapiraca, Brazil.
  • Silva Santos LD; Molecular Biology and Gene Expression Laboratory (LABMEG), Federal University of Alagoas, Arapiraca, Brazil.
  • de Souza Praxedes FA; Molecular Biology and Gene Expression Laboratory (LABMEG), Federal University of Alagoas, Arapiraca, Brazil.
  • Sathio Bessoni Tanabe I; Molecular Biology and Gene Expression Laboratory (LABMEG), Federal University of Alagoas, Arapiraca, Brazil.
  • Fireman de Farias K; Molecular Biology and Gene Expression Laboratory (LABMEG), Federal University of Alagoas, Arapiraca, Brazil.
  • Martins de Souza Figueiredo EV; Molecular Biology and Gene Expression Laboratory (LABMEG), Federal University of Alagoas, Arapiraca, Brazil.
Immunol Invest ; 52(2): 154-161, 2023 Feb.
Article em En | MEDLINE | ID: mdl-36394557
BACKGROUND: Dengue is a life-threatening disease. The factors that lead to severe cases are not completely understood. The host immune system is involved in the response to infections and plays an important role in dengue infection. IL-6 and iNOS are components of the immune system and genetic polymorphisms in these genes may be involved in dengue virus infection. The study aimed to investigate the association of genetic polymorphisms in the IL6 and iNOS genes and dengue. METHODS: We performed a case-control study using 60 dengue-infected individuals and 119 healthy controls. Polymorphisms in the IL6 (T15A) and iNOS (-1173CT) genes were amplified by Real-Time PCR. Statistical analyses were performed using BioEstat 5.0. RESULTS: We identified that the frequency of T/A genotype of IL6 was higher in dengue fever patients and C/T genotype of iNOS was higher in dengue hemorrhagic fever patients, however, no association was found between these polymorphisms and dengue. CONCLUSION: Polymorphisms in iNOS and IL6 were not associated with dengue infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-6 / Dengue Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Immunol Invest Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-6 / Dengue Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Immunol Invest Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido