Association Between Depressive Symptoms and Cardiac Structure and Function in a Peruvian Population.

Santiago, Christine; Peña, Melissa Burroughs; Brown, Timothy; Shakil, Saate; Januzzi, James; Velazquez, Eric; Miranda, J Jaime; Rivera, Danny; Checkley, William

Santiago, Christine; Peña, Melissa Burroughs; Brown, Timothy; Shakil, Saate; Januzzi, James; Velazquez, Eric; Miranda, J Jaime; Rivera, Danny; Checkley, William.

Afiliação

Santiago C; Stanford Department of Medicine, Palo Alto CA, USA.
Peña MB; School of Public Health, University of California, Berkeley, Berkeley, CA.
Brown T; Division of Cardiology, Stanford Health Care, Oakland, CA, USA.
Shakil S; School of Public Health, University of California, Berkeley, Berkeley, CA.
Januzzi J; Division of Cardiology, University of Washington, Seattle, Washington, USA.
Velazquez E; Division of Cardiology, Department of Medicine, Mass General Hospital, MA, USA.
Miranda JJ; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Rivera D; CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
Checkley W; Department of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.

Glob Heart ; 17(1): 78, 2022.

Article em En | MEDLINE | ID: mdl-36382157

RESUMO

Depressive disorders are a leading cause of disability and are globally pervasive. It is estimated that 80% of depression occurs in low-income and middle-income countries. Depression is associated with worse outcomes in patients with cardiac disease including heart failure (HF); however, mechanistic understanding to explain heightened risk in HF remains poorly characterized. We examined the association between depressive symptoms and cardiac structure and function by transthoracic echocardiography. We selected a random sample of adult participants in Puno and Pampas de San Juan de Miraflores, Peru, from the CRONICAS cohort study. Depression symptoms were self-reported and measured with the Center for Epidemiological Studies Depression Scale in 2010. Participants underwent transthoracic echocardiography in 2014. Multivariable linear regression was used to examine the relationship between depressive symptoms and echocardiographic measures of cardiac structure and function and was adjusted for relevant covariates. Three hundred and seventy-three participants (mean age 56.7 years, 57% female) were included in this analysis of which 91 participants (24%) had clinically significant depressive symptoms. After adjustment, clinically significant depressive symptoms were associated with a reduced diastolic relaxation velocity compared to non-depressed subjects (-0.72 cm/s, 95% CI -1.21 to -0.24, p = 0.004). Other differences between depressed and non- depressed participants were less obvious. In conclusion, clinically significant depressive symptoms were associated with a lower septal e' velocity in the Peruvian population. Depressive symptoms were not obviously associated with other abnormalities in cardiac structure or function.

Assuntos

Depressão; Insuficiência Cardíaca; Adulto; Humanos; Feminino; Pessoa de Meia-Idade; Masculino; Depressão/epidemiologia; Peru/epidemiologia; Estudos de Coortes; Ecocardiografia; Insuficiência Cardíaca/epidemiologia

Palavras-chave

Depression; Diastolic Function; Echocardiography

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Depressão / Insuficiência Cardíaca Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Peru Idioma: En Revista: Glob Heart Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido

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