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Variables associated with progression of moderate-to-severe Crohn's disease.
Sacramento, Carolina da Silva Beda; Motta, Marina Pamponet; Alves, Candida de Oliveira; Mota, Jaciane Araujo; Codes, Lina Maria Goes de; Ferreira, Reginaldo Freitas; Silva, Pedro de Almeida; Palmiro, Larissa do Prado; Barbosa, Rafael Miranda; Andrade, Mariana Nery; Andrade, Vitor Damasceno; Vasconcelos, Vitor Brandão; Thiara, Bernardo Wasconcellos; Netto, Eduardo Martins; Santana, Genoile Oliveira.
Afiliação
  • Sacramento CDSB; Department of Gastroenterology, Hospital Universitário Professor Edgard Santos, Salvador, Brazil.
  • Motta MP; Department of Gastroenterology, Hospital Universitário Professor Edgard Santos, Salvador, Brazil.
  • Alves CO; Department of Gastroenterology, Hospital Universitário Professor Edgard Santos, Salvador, Brazil.
  • Mota JA; Department of Gastroenterology, Hospital Geral Roberto Santos, Salvador, Brazil.
  • Codes LMG; Department of Proctology, Hospital Universitario Professor Edgard Santos, Salvador, Brazil.
  • Ferreira RF; Universidade do Estado da Bahia, Salvador, Brazil.
  • Silva PA; Universidade do Estado da Bahia, Salvador, Brazil.
  • Palmiro LDP; Universidade do Estado da Bahia, Salvador, Brazil.
  • Barbosa RM; Universidade do Estado da Bahia, Salvador, Brazil.
  • Andrade MN; Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil.
  • Andrade VD; Universidade Salvador, Salvador, Brazil.
  • Vasconcelos VB; Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil.
  • Thiara BW; Universidade Salvador, Salvador, Brazil.
  • Netto EM; Universidade Federal da Bahia, Salvador, Brazil.
  • Santana GO; Ciências da Vida, Universidade do Estado da Bahia, Salvador, Brazil genoile@uol.com.br.
BMJ Open Gastroenterol ; 9(1)2022 11.
Article em En | MEDLINE | ID: mdl-36379617
OBJECTIVE: Determine the variables associated with hospitalisations in patients with Crohn's disease and those associated with surgery, intestinal resection, hospital readmission, need for multiple operations and immunobiological agent use. DESIGN: A cross-sectional study was conducted from 2019 to 2021, using two centres for inflammatory bowel diseases in the Brazilian Public Health System. RESULTS: This study included 220 patients. Only perianal disease was associated with hospitalisation (31.6% vs 13.0%, p=0.012). Stricturing or penetrating behaviour (35.8% vs 12.6%, p<0.001) and perianal disease (45.9% vs 9.9%, p<0.001) were associated with surgery. Ileal or ileocolonic location (80.0% vs 46.5%, p=0.044) and stricturing or penetrating behaviour (68.0% vs 11.2%, p<0.001) were associated with intestinal resection. Steroids use at first Crohn's disease occurrence and postoperative complications were associated with hospital readmission and need for multiple operations, respectively. Age below 40 years at diagnosis (81.3% vs 62.0%, p=0.004), upper gastrointestinal tract involvement (21.8% vs 10.3%, p=0.040) and perianal disease (35.9% vs 16.3%, p<0.001) were associated with immunobiological agent use. CONCLUSION: Perianal disease and stricturing or penetrating behaviour were associated with more than one significant outcome. Other variables related to Crohn's disease progression were age below 40 years at diagnosis, an ileal or ileocolonic disease localisation, an upper gastrointestinal tract involvement, the use of steroids at the first Crohn's disease occurrence and history of postoperative complications. These findings are similar to those in the countries with a high prevalence of Crohn's disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Crohn Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: BMJ Open Gastroenterol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Crohn Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: BMJ Open Gastroenterol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido