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Chemical characterization and microencapsulation of extracellular fungal pigments.
Contreras-Machuca, Paulina I; Avello, Marcia; Pastene, Edgar; Machuca, Ángela; Aranda, Mario; Hernández, Vicente; Fernández, Marcos.
Afiliação
  • Contreras-Machuca PI; Pharmacognosy Laboratory, Department of Pharmacy, Faculty of Pharmacy, Universidad de Concepción, Concepción, Chile. paucontrerasm@udec.cl.
  • Avello M; Pharmaceutical Technology Laboratory, Department of Pharmacy, Universidad de Concepción, Concepción, Chile. paucontrerasm@udec.cl.
  • Pastene E; Pharmacognosy Laboratory, Department of Pharmacy, Faculty of Pharmacy, Universidad de Concepción, Concepción, Chile.
  • Machuca Á; Laboratory of Synthesis and Biotransformation of Natural Products, Universidad del Bio Bio, Chillán, Chile.
  • Aranda M; Fungal Biotechnology Laboratory, Department of Plant Sciences and Technology, Universidad de Concepción, Campus Los Angeles, Los Angeles, Chile. angmachu@udec.cl.
  • Hernández V; Food and Drug Research Laboratory, Department of Pharmacy, Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Fernández M; Faculty of Forestry, Universidad de Concepción, Concepción, Chile.
Appl Microbiol Biotechnol ; 106(24): 8021-8034, 2022 Dec.
Article em En | MEDLINE | ID: mdl-36370157
In this work, extracellular colored metabolites obtained from the filamentous fungi Talaromyces australis and Penicillium murcianum, isolated in the Andean-Patagonian native forests of Chile, were studied as prospect compounds to increase the sustainability of cosmetic products. The chemical and antioxidant properties of these natural pigments were characterized and strategies for their microencapsulation were also studied. UHPLC/MS-MS analyses indicated that the predominant metabolites detected in the cultures of P. murcianum were monascin (m/z = 411.15) and monashexenone (m/z = 319.10), while athrorosin H (m/z = 458.20) and damnacanthal (m/z = 281.05) were detected in cultures of T. australis. ORAC tests revealed that P. murcianum's metabolites had the greatest antioxidant properties with values higher than 2000 µmol of trolox equivalents/g. The fungal metabolites were successfully microencapsulated by ionic gelation into structures made of 1.3% sodium alginate, 0.2% chitosan, and 0.07% hyaluronic acid. The microencapsulation process generated structures of 543.57 ± 0.13 µm of mean diameter (d50) with an efficiency of 30% for P. murcianum, and 329.59 ± 0.15 µm of mean diameter (d50) and 40% efficiency, for T. australis. The chemical and biological characterization show the biotechnological potential of these fungal species to obtain pigments with antioxidant activity that could be useful in the cosmetic industry. The encapsulation process enables the production of easy-to-handle dry powder from the fungal metabolites, which could be potentially marketed as a functional cosmetic ingredient. KEY POINTS: • The predominant fungal pigments were of azaphilone and anthraquinoid classes. • The fungal pigments showed high antioxidant activity by ORAC assay. • Fungal pigment microcapsules obtained by ionic gelation were characterized.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biotecnologia / Antioxidantes Idioma: En Revista: Appl Microbiol Biotechnol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Chile País de publicação: Alemanha
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biotecnologia / Antioxidantes Idioma: En Revista: Appl Microbiol Biotechnol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Chile País de publicação: Alemanha