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lncRNAs dysregulation in monocytes from primary antiphospholipid syndrome patients: a bioinformatic and an experimental proof-of-concept approach.
Guzmán-Martín, Carlos A; Juárez-Vicuña, Yaneli; Domínguez-López, Aarón; González-Ramírez, Javier; Amezcua-Guerra, Luis M; Martínez-Martínez, Laura A; Sánchez-Muñoz, Fausto.
Afiliação
  • Guzmán-Martín CA; Maestría en Ciencias de la Salud, Posgrado de la Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico.
  • Juárez-Vicuña Y; Departamento de Inmunología, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, 14080, Mexico City, Mexico.
  • Domínguez-López A; Departamento de Inmunología, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, 14080, Mexico City, Mexico.
  • González-Ramírez J; Maestría en Ciencias de la Salud, Posgrado de la Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico.
  • Amezcua-Guerra LM; Laboratorio de Biología Celular, Facultad de Enfermería, Universidad Autónoma de Baja California Campus Mexicali, Mexicali, Baja California, Mexico.
  • Martínez-Martínez LA; Departamento de Inmunología, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, 14080, Mexico City, Mexico.
  • Sánchez-Muñoz F; Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, Mexico City, Mexico.
Mol Biol Rep ; 50(1): 937-941, 2023 Jan.
Article em En | MEDLINE | ID: mdl-36367661
BACKGROUND: Antiphospholipid syndrome (APS) is the main cause of acquired thrombophilia where peripheral circulating cells such as monocytes have a key role. Currently, several studies have linked long non-coding RNAs (lncRNAs) in different inflammatory and autoimmune processes, including lupus. However, the role of lncRNAs in antiphospholipid syndrome is unknown, therefore, we aimed to select and measure expression levels of three lncRNAs based on its abundance in monocytes from APS patients. METHODS: Selection of lncRNAs candidates were carried out based on its abundance in monocytes and their relationship with Perez-Sanchez miRNA signature by using miRNet 2.0 bioinformatic tool, then lncRNAs expression levels was measured in monocytes by RT-qPCR. RESULTS: This is the first study to report that lncRNAs: FGD5-AS1, OIP5-AS1 and GAS5 are promising candidates for play a role on APS monocytes and they are expressed differently between patients and controls. CONCLUSIONS: OIP5-AS1, FGD5-AS1 and GAS5 are downregulated on monocytes from APS patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Antifosfolipídica / MicroRNAs / RNA Longo não Codificante Limite: Humans Idioma: En Revista: Mol Biol Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: México País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Antifosfolipídica / MicroRNAs / RNA Longo não Codificante Limite: Humans Idioma: En Revista: Mol Biol Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: México País de publicação: Holanda