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The Anxiolytic Activity of Schinus terebinthifolia Leaf Lectin (SteLL) Is Dependent on Monoaminergic Signaling although Independent of the Carbohydrate-Binding Domain of the Lectin.
Lima, Bárbara Raíssa Ferreira de; Patriota, Leydianne Leite de Siqueira; Marinho, Amanda de Oliveira; Costa, Jainaldo Alves da; Napoleão, Thiago Henrique; Rosa, Michelle Melgarejo da; Paiva, Patrícia Maria Guedes.
Afiliação
  • Lima BRF; Department of Biochemistry, Biosciences Center, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.
  • Patriota LLS; Department of Biochemistry, Biosciences Center, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.
  • Marinho AO; Department of Biochemistry, Biosciences Center, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.
  • Costa JAD; Department of Biochemistry, Biosciences Center, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.
  • Napoleão TH; Department of Biochemistry, Biosciences Center, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.
  • Rosa MMD; Department of Biochemistry, Biosciences Center, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.
  • Paiva PMG; Therapeutic Innovation Research Center Suely Galdino (NUPIT), Federal University of Pernambuco, Recife 50670-420, PE, Brazil.
Pharmaceuticals (Basel) ; 15(11)2022 Nov 07.
Article em En | MEDLINE | ID: mdl-36355536
The potential of plant lectins (carbohydrate-binding proteins) for the treatment of neurological disorders such as anxiety and depression has started to be reported in the last few years. Schinus terebinthifolia leaves contain a lectin called SteLL, which has displayed antimicrobial, immunomodulatory, antitumor, and analgesic activities. However, the effects of SteLL on the Central Nervous System (CNS) have not yet been determined. In this study, we investigated the in vivo anxiolytic effect of SteLL in mice using the open field (OF) and elevated plus maze (EPM) tests. In the OF, SteLL (1, 2, and 4 mg/kg, i.p.) did not interfere with the number of crossings but significantly reduced the number of rearings. In the EPM, SteLL 4 mg/kg and the combination SteLL (1 mg/kg) plus diazepam (1 mg/kg) significantly increased the time spent in the open arms while reducing the time spent in the closed arms. The anxiolytic effect of SteLL did not seem to be dependent on the carbohydrate-binding domain of the lectin. Nevertheless, the SteLL effect in the EPM was reversed by the pretreatment with the pharmacological antagonists of the α2-adrenoceptor, 5-HT2A/2C serotonin receptor, and the D1 dopamine receptor. Overall, our results suggest that the anxiolytic effect of SteLL is dependent on the monoaminergic signaling cascade.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça