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Varicocele-Associated Infertility and the Role of Oxidative Stress on Sperm DNA Fragmentation.
Wood, Guilherme Jacom Abdulmassih; Cardoso, João Paulo Greco; Paluello, Davi Vischi; Nunes, Thiago Fagundes; Cocuzza, Marcello.
Afiliação
  • Wood GJA; Huntington Medicina Reprodutiva, São Paulo, Brazil.
  • Cardoso JPG; Division of Urology, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
  • Paluello DV; Division of Urology, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
  • Nunes TF; Division of Urology, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
  • Cocuzza M; Huntington Medicina Reprodutiva, São Paulo, Brazil.
Front Reprod Health ; 3: 695992, 2021.
Article em En | MEDLINE | ID: mdl-36304050
Varicocele has been extensively described and studied as the most important reversible cause of male infertility. Its impact on semen parameters, pregnancy rates, and assisted reproductive outcomes have been associated with multifactorial aspects, most of them converging to increase of reactive oxygen species (ROS). More recently, sperm DNA fragmentation has gained significant attention and potential clinical use, although the body of evidence still needs further evolution. The associations between sperm DNA damage and a variety of disorders, including varicocele itself, share common pathways to ROS increase. This mini-review discusses different aspects related to the etiology of ROS and its relation to varicocele and potential mechanisms of DNA damage.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Front Reprod Health Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Front Reprod Health Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça