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Baccharis trimera Infusion Reduces Macrophages Activation and High-Fat Diet-Induced Metabolic Disorders in Mice.
Ximenes, Thalita Vieira Nascimento; Carvalho, Raquel; Bonfá, Iluska Senna; Santos, Vanessa Samúdio; Candeloro, Luciane; Alves, Flávio Macedo; Silva, Denise Brentan; Carollo, Carlos Alexandre; Gielow, Karine de Cássia Freitas; Silva-Filho, Saulo Euclides; Toffoli-Kadri, Mônica Cristina.
Afiliação
  • Ximenes TVN; Pharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
  • Carvalho R; Pharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
  • Bonfá IS; Pharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
  • Santos VS; Pharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
  • Candeloro L; Biosciences Institute, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
  • Alves FM; Biosciences Institute, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
  • Silva DB; Pharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
  • Carollo CA; Pharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
  • Gielow KCF; Pharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
  • Silva-Filho SE; Pharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
  • Toffoli-Kadri MC; Pharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
Pharmaceuticals (Basel) ; 15(10)2022 Oct 13.
Article em En | MEDLINE | ID: mdl-36297370
The aim of this study is to evaluate the efficacy of Baccharis trimera infusion on high-fat diet-induced metabolic disorders in mice and macrophages activation. This study evaluated obesity, insulin resistance, dyslipidemia and hepatic steatosis induced by a high-fat diet in Swiss mice. Cellular parameters in macrophages, such as cell viability (MTT), the production and release of nitric oxide (NO) and hydrogen peroxide (H2O2), cell spreading, cell adhesion and phagocytosis were determined. Our results showed that treatment with B. trimera prevented the mentioned conditions, except for the production of hydrogen peroxide. B. trimera prevented the development of obesity and associated comorbidities, as well as activation of macrophages. In conclusion, B. trimera is able to prevent obesity and metabolic disorders and macrophages activation, minimizing inflammation and validating the popular use of this plant tea.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça