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New FIB-4 and NFS cutoffs to guide sequential non-invasive assessment of liver fibrosis by magnetic resonance elastography in NAFLD.
Torres, Louise; Schuch, Alice; Longo, Larisse; Valentini, Bruna Bressan; Galvão, Gabriela Schneider; Luchese, Eduardo; Pinzon, Carlos; Bartels, Rodrigo; Álvares-da-Silva, Mário Reis.
Afiliação
  • Torres L; Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, Rio Grande do Sul, Brazil; Department of Radiology, Hospital Moinhos de Vento, Porto Alegre 90035-000, Rio Grande do Sul, Brazil.
  • Schuch A; Department of Radiology, Hospital Moinhos de Vento, Porto Alegre 90035-000, Rio Grande do Sul, Brazil.
  • Longo L; Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, Rio Grande do Sul, Brazil.
  • Valentini BB; Department of Radiology, Hospital Moinhos de Vento, Porto Alegre 90035-000, Rio Grande do Sul, Brazil.
  • Galvão GS; Department of Radiology, Hospital Moinhos de Vento, Porto Alegre 90035-000, Rio Grande do Sul, Brazil.
  • Luchese E; Gastroenterology and Hepatology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, Rio Grande do Sul, Brazil.
  • Pinzon C; Gastroenterology and Hepatology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, Rio Grande do Sul, Brazil.
  • Bartels R; Department of Radiology, Hospital Moinhos de Vento, Porto Alegre 90035-000, Rio Grande do Sul, Brazil.
  • Álvares-da-Silva MR; Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, Rio Grande do Sul, Brazil; Gastroenterology and Hepatology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, Rio Grande do Sul, Brazil. Electronic address: ma
Ann Hepatol ; 28(1): 100774, 2023.
Article em En | MEDLINE | ID: mdl-36280013
INTRODUCTION AND OBJECTIVES: Liver fibrosis is an important prognosis marker in non-alcoholic fatty liver disease (NAFLD). Biopsy has been considered the gold-standard method for measuring liver fibrosis; however, it is an invasive procedure. Non-invasive diagnostic tools have been developed, such as clinical scores and magnetic resonance elastography (MRE), which is the most accurate non-invasive method to determine liver fibrosis. Thus, the aim was to determine the NAFLD Fibrosis Score (NFS) and the Fibrosis-4 Score (FIB-4) cut-off points that best identify NAFLD patients at risk for developing liver fibrosis. PATIENTS AND METHODS: Single-center cross-sectional study with prospective recruitment of NAFLD (training-cohort) and MAFLD (validation-cohort) patients undergoing MRE. The NFS and the FIB-4 cut-off points that best-differentiated patients with fibrosis, using the MRE as the standard method, were determined. RESULTS: Two cohorts were analyzed, a training cohort that included the initial 183 patients with NAFLD and a validation cohort that included 289 patients. In the training cohort, 60.1% had mild steatosis and 11.5% had liver fibrosis ≥ F1 by MRE. ROC curves were developed for FIB-4 and NFS, and the cut-off points chosen were 1.505 (sensitivity=85% and specificity=86%) for FIB-4 and -0.835 (sensitivity=100% and specificity=70%) for NFS, showing greater specificity than the cut-off points currently used (51% and 76%, respectively). The two cohorts exhibited similar characteristics and similar sensitivity and specificity results for the chosen cut-off points. CONCLUSIONS: This study has shown cut-off points with greater specificity and excellent sensitivity to guide the indication for further liver evaluation by MRE in NAFLD patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Técnicas de Imagem por Elasticidade / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Ann Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: México
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Técnicas de Imagem por Elasticidade / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Ann Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: México