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Use of autologous platelet-rich plasma in androgenetic alopecia in women: a systematic review and meta-analysis.
de Oliveira, Antonio Flávio Queiroz; Arcanjo, Francisco Plácido Nogueira; Rodrigues, Maria Rosineida Paiva; Rosa E Silva, Ana Augusta; Hall, Peter Richard.
Afiliação
  • de Oliveira AFQ; Postgraduate Program in Health Sciences, Federal University of Ceará, Sobral, Brazil.
  • Arcanjo FPN; Postgraduate Program in Health Sciences, Federal University of Ceará, Sobral, Brazil.
  • Rodrigues MRP; Faculty of Medicine, Federal University of Ceará, Sobral, Brazil.
  • Rosa E Silva AA; Faculty of Medicine, Centro Universitário INTA, Sobral, Brazil.
  • Hall PR; Faculty of Medicine, Centro Universitário INTA, Sobral, Brazil.
J Dermatolog Treat ; 34(1): 2138692, 2023 Dec.
Article em En | MEDLINE | ID: mdl-36264022
OBJECTIVE: To conduct a systematic review and meta-analysis to verify the efficacy of using autologous platelet-rich plasma (PRP) in female pattern alopecia (FPA). BACKGROUND: Androgenetic alopecia is the leading cause of hair loss in men andwomen and often impacts self-esteem and quality of life. DATA SOURCES: MEDLINE/PubMed, Cochrane Library, ClinicalTrials.gov, and EMBASE up to May 2021. STUDY SELECTION AND DATA EXTRACTION: We identified all studies evaluating the effect of PRP in FPA. A narrative synthesis was performed from data on the efficacy of PRP treatment and adverse effects; quantitative results of PRP use compared to control treatment for female androgenetic alopecia (AGA) were synthesized. The outcomes analyzed were terminal density and hair thickness. RESULTS: Seven articles were selected for this review. Meta-analysis showed that PRP-based interventions were able to increase terminal hair density compared to control (standardized mean difference (SMD)=2.98, 95% confidence intervals (CIs)=1.10, 4.85), with no significant increase in hair thickness (SMD = 1.16, 95% CI= -0.96, 3.28). During and after treatment, no major side effects were reported by patients or researchers. CONCLUSIONS: The use of autologous PRP injections in female AGA seems to be promising, with more consistent results on terminal hair density. However, caution is recommended in the interpretation of these results until they can be replicated in larger and more representative samples. PROSPERO registration number CRD42021257154.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Plasma Rico em Plaquetas Tipo de estudo: Systematic_reviews Aspecto: Patient_preference Limite: Female / Humans / Male Idioma: En Revista: J Dermatolog Treat Assunto da revista: DERMATOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Plasma Rico em Plaquetas Tipo de estudo: Systematic_reviews Aspecto: Patient_preference Limite: Female / Humans / Male Idioma: En Revista: J Dermatolog Treat Assunto da revista: DERMATOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido