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Reduction in Serum Magnesium Levels and Renal Function Are Associated with Increased Mortality in Obese COVID-19 Patients.
Pulido Perez, Patricia; Póndigo de Los Angeles, Jorge Alberto; Perez Peralta, Alonso; Ramirez Mojica, Eloisa; Torres Rasgado, Enrique; Hernandez-Hernandez, Maria Elena; Romero, Jose R.
Afiliação
  • Pulido Perez P; Faculty of Medicine, Autonomous University of Puebla, 13 Sur 2901 Col. Volcanes, Puebla 72420, Mexico.
  • Póndigo de Los Angeles JA; Internal Medicine Department, University Hospital of Puebla, Mexico. Av 27 Poniente, Los Volcanes, Puebla 72410, Mexico.
  • Perez Peralta A; Internal Medicine Department, University Hospital of Puebla, Mexico. Av 27 Poniente, Los Volcanes, Puebla 72410, Mexico.
  • Ramirez Mojica E; Internal Medicine Department, University Hospital of Puebla, Mexico. Av 27 Poniente, Los Volcanes, Puebla 72410, Mexico.
  • Torres Rasgado E; Faculty of Medicine, Autonomous University of Puebla, 13 Sur 2901 Col. Volcanes, Puebla 72420, Mexico.
  • Hernandez-Hernandez ME; Faculty of Medicine, Autonomous University of Puebla, 13 Sur 2901 Col. Volcanes, Puebla 72420, Mexico.
  • Romero JR; Doctorate in Biological Science, Autonomous University of Tlaxcala, La Loma Xicohtencatl, Tlaxcala 90070, Mexico.
Nutrients ; 14(19)2022 Sep 29.
Article em En | MEDLINE | ID: mdl-36235704
Several studies provide evidence that obesity is a significant risk factor for adverse outcomes in coronavirus disease 2019 (COVID-19). Altered renal function and disturbances in magnesium levels have been reported to play important pathophysiological roles in COVID-19. However, the relationship between obesity, renal function, circulating magnesium levels, and mortality in patients with COVID-19 remains unclear. In this retrospective cohort study, we characterized 390 hospitalized patients with COVID-19 that were categorized according to their body mass index (BMI). Patients were clinically characterized and biochemical parameters, renal function, and electrolyte markers measured upon admission. We found that in patients who died, BMI was associated with reduced estimated glomerular filtration rate (eGFR, Rho: −0.251, p = 0.001) and serum magnesium levels (Rho: −0.308, p < 0.0001). Multiple linear regression analyses showed that death was significantly associated with obesity (p = 0.001). The Cox model for obese patients showed that magnesium levels were associated with increased risk of death (hazard ratio: 0.213, 95% confidence interval: 0.077 to 0.586, p = 0.003). Thus, reduced renal function and lower magnesium levels were associated with increased mortality in obese COVID-19 patients. These results suggest that assessment of kidney function, including magnesium levels, may assist in developing effective treatment strategies to reduce mortality among obese COVID-19 patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Insuficiência Renal / COVID-19 Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Nutrients Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Insuficiência Renal / COVID-19 Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Nutrients Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Suíça