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Semisynthetic Abietic and Dehydroabietic Acid Derivatives and Triptoquinone Epimers Interfere with LPS-Triggered Activation of Dendritic Cells.
Sierra, Jelver A; Gilchrist, Katherine; Tabares-Guevara, Jorge H; Betancur-Galvis, Liliana; Ramirez-Pineda, Jose R; González-Cardenete, Miguel A.
Afiliação
  • Sierra JA; Grupo Inmunomodulación, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín 050010, Colombia.
  • Gilchrist K; Grupo Inmunomodulación, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín 050010, Colombia.
  • Tabares-Guevara JH; Grupo Inmunomodulación, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín 050010, Colombia.
  • Betancur-Galvis L; Grupo de Investigación Dermatológica, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín 050010, Colombia.
  • Ramirez-Pineda JR; Grupo Inmunomodulación, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín 050010, Colombia.
  • González-Cardenete MA; Instituto de Tecnología Química, Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas, Avda. de los Naranjos s/n, 46022 Valencia, Spain.
Molecules ; 27(19)2022 Oct 08.
Article em En | MEDLINE | ID: mdl-36235219
Abietic acid (AA), dehydroabietic acid (DHA) and triptoquinones (TQs) are bioactive abietane-type diterpenoids, which are present in many edible vegetables and medicinal herbs with health-promoting properties. Evidence suggests that beneficial effects of diterpenes operate, at least in part, through effects on cells in the immune system. Dendritic cells (DCs) are a key type of leukocyte involved in the initiation and regulation of the immune/inflammatory response and natural or synthetic compounds that modulate DC functions could be potential anti-inflammatory/immunomodulatory agents. Herein, we report the screening of 23 known semisynthetic AA and DHA derivatives, and TQs, synthesized previously by us, in a multi-analyte DC-based assay that detects inhibition of pro-inflammatory cytokine production. Based on the magnitude of the inhibitory effect observed and the number of cytokines inhibited, a variety of activities among compounds were observed, ranging from inactive/weak to very potent inhibitors. Structurally, either alcohol or methyl ester substituents on ring A along with the introduction of aromaticity and oxidation in ring C in the abietane skeleton were found in compounds with higher inhibitory properties. Two DHA derivatives and two TQs exhibited a significant inhibition in all pro-inflammatory cytokines tested and were further investigated. The results confirmed their ability to inhibit, dose dependently, LPS-stimulated expression of the co-stimulatory molecules CD40 and/or CD86 and the production of the pro-inflammatory cytokines IL-1ß, IL-6, IL-12 and TNFα. Our results demonstrate that DC maturation process can be targeted by semisynthetic DHA derivatives and TQ epimers and indicate the potential of these compounds as optimizable anti-inflammatory/immunomodulatory agents.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Abietanos Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Abietanos Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Suíça