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Osteocalcin and Runx2 Expression in Anterior Maxillary Reconstructions Using Bone Xenografts Associated to Bone Marrow Aspirate Concentrate.
Hergemöller, Daniel Fernando; Pelegrine, André Antonio; Pasquali, Paulo José; Scavone de Macedo, Luis Guilherme; Teixeira, Marcelo Lucchesi; Moy, Peter Karyen; Aloise, Antonio Carlos.
Afiliação
  • Hergemöller DF; Department of Implantology, São Leopoldo Mandic School of Dentistry, Campinas, SP, Brazil.
  • Pelegrine AA; Department of Implantology, São Leopoldo Mandic School of Dentistry, Campinas, SP, Brazil.
  • Pasquali PJ; Department of Implantology, São Leopoldo Mandic School of Dentistry, Campinas, SP, Brazil.
  • Scavone de Macedo LG; Department of Implantology, São Leopoldo Mandic School of Dentistry, Campinas, SP, Brazil.
  • Teixeira ML; Department of Implantology, São Leopoldo Mandic School of Dentistry, Campinas, SP, Brazil.
  • Moy PK; Department of Oral and Maxillofacial Surgery, School of Dentistry, University of California, Los Angeles, CA, USA.
  • Aloise AC; Department of Implantology, São Leopoldo Mandic School of Dentistry, Campinas, SP, Brazil.
Contemp Clin Dent ; 13(3): 211-216, 2022.
Article em En | MEDLINE | ID: mdl-36213846
Background: It is known that a large number of mediators involved in osteogenesis can influence bone development and repair; however, whether these mediators could be used as markers of bone maturity has yet to be determined. Aim: To evaluate the expression of osteocalcin (OC) and Runt-related transcription factor 2 (Runx2) in bone biopsies obtained during the reconstruction of atrophic anterior maxillae using particulate bone xenografts with or without association of autogenous bone marrow aspirate concentrate (BMAC). Materials and Methods: Ten patients were distributed into two groups (n = 5), according to the type of grafting material used: Control group (CG), particulate bone xenograft alone, and test group (TG), particulate bone xenograft combined with BMAC. A bone specimen was removed from the graft area 4 months after grafting, before implant placement. The specimens were processed and submitted to immunohistochemical analysis for detection of OC and Runx2. Histomorphometry was used to ascertain the percentage of stained areas in both groups. The Wilcoxon Mann-Whitney U-Test was used in the statistical analysis (P < 0.05). Results: The immunohistochemical analysis revealed a significantly higher OC expression in the TG than in the CG, namely 27.40 ± 1.34% and 11.40 ± 2.70%, respectively (P < 0.05), and a significantly higher Runx2 expression in the TG than in the CG, namely 2.80 ± 0.84% and 0.40 ± 0.55%, respectively (P < 0.05). Conclusion: The OC and Runx2 expression levels were higher when BMAC was associated with the bone xenograft than when it was not.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Contemp Clin Dent Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Índia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Contemp Clin Dent Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Índia