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Fourier Transform Infrared Spectroscopy (FT-IR) of Pseudomonas aeruginosa post photodynamic therapy with Curcumin in vitro.
Marques, Camila Monteiro Santos; Pedroso, Juliana Teixeira; Bhattacharjee, Tanmoy; Pupin, Breno; Pinto, Juliana Guerra; Ferreira-Strixino, Juliana; Sakane, Kumiko Koibuchi.
Afiliação
  • Marques CMS; Infrared Spectroscopy Laboratory, Research and Development Institute R&DI, University of Vale do Paraíba - Univap. Shishima Hifumi Avenue, 2911, 12244-000, São Jose dos Campos, São Paulo, Brazil.
  • Pedroso JT; Photobiology Applied to Health (PhotoBios) - Research and Development Institute - R&DI, University of Vale do Paraiba, Univap. Shishima Hifumi Avenue 2911, 12244-000, São José dos Campos, São Paulo, Brazil.
  • Bhattacharjee T; Sir John Walsh Research Institute, 310 Great King Street, Dunedin 9016, New Zealand.
  • Pupin B; Infrared Spectroscopy Laboratory, Research and Development Institute R&DI, University of Vale do Paraíba - Univap. Shishima Hifumi Avenue, 2911, 12244-000, São Jose dos Campos, São Paulo, Brazil.
  • Pinto JG; Photobiology Applied to Health (PhotoBios) - Research and Development Institute - R&DI, University of Vale do Paraiba, Univap. Shishima Hifumi Avenue 2911, 12244-000, São José dos Campos, São Paulo, Brazil.
  • Ferreira-Strixino J; Photobiology Applied to Health (PhotoBios) - Research and Development Institute - R&DI, University of Vale do Paraiba, Univap. Shishima Hifumi Avenue 2911, 12244-000, São José dos Campos, São Paulo, Brazil. Electronic address: juguerra@univap.br.
  • Sakane KK; Infrared Spectroscopy Laboratory, Research and Development Institute R&DI, University of Vale do Paraíba - Univap. Shishima Hifumi Avenue, 2911, 12244-000, São Jose dos Campos, São Paulo, Brazil.
Spectrochim Acta A Mol Biomol Spectrosc ; 285: 121916, 2023 Jan 15.
Article em En | MEDLINE | ID: mdl-36201868
Alternative therapies against pathogens are under intense investigation because of their increasing resistance to antibiotics. Photodynamic therapy (PDT) is one such alternative that has shown promising results. However, for the widespread use of PDT, it is essential to decipher underlying mechanisms, so as to improve PDT's therapeutic applications. Because of this, we have studied biochemical changes in pathogen Pseudomonas aeruginosa, a medically important bacteria that has developed antibiotic resistance, after PDT with curcumin photosensitizer. Results show a drastic decrease in α-helix protein and increased disordered and ß-sheet secondary structure proteins in P. Aeruginosa post-PDT compared to control. Interestingly, these biochemical changes differ from PDT of pathogens Leishmania braziliensis and Leishmania major with photosensitizer methylene blue. This observation underlines the need for extensive studies on PDT of different pathogens to understand mechanisms of action and develop better PDT strategies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Curcumina Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Curcumina Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido