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Clinical characteristics and laboratory parameters associated with the risk of severe COVID-19 in patients from two hospitals in Northeast Brazil.
Araújo, Sara Larissa de Melo; Feitosa, Thiala Alves; Pereira, Vanessa Cardoso; Andrade, Clara Caldeira de; Silva, Ana Tércia Paulo; Andrade, Lorena Viana de; Lopes, Kamila Erika Ribeiro; Sá, Mirela Vanessa de Souza; Souza, Carlos Dornels Freire de; Armstrong, Anderson da Costa; Carmo, Rodrigo Feliciano do.
Afiliação
  • Araújo SLM; Universidade Federal do Vale do São Francisco, Programa de Pós-graduação em Ciências da Saúde e Biológicas, Petrolina, PE, Brasil.
  • Feitosa TA; Universidade Federal do Vale do São Francisco, Programa de Pós-graduação em Biociências, Petrolina, PE, Brasil.
  • Pereira VC; Prefeitura de Petrolina, Petrolina, PE, Brasil.
  • Andrade CC; Universidade Federal do Vale do São Francisco, Programa de Pós-graduação em Biociências, Petrolina, PE, Brasil.
  • Silva ATP; Universidade Federal do Vale do São Francisco, Colegiado de Ciências Biológicas, Petrolina, PE, Brasil.
  • Andrade LV; Universidade Federal do Vale do São Francisco, Colegiado de Ciências Biológicas, Petrolina, PE, Brasil.
  • Lopes KER; Universidade Federal do Vale do São Francisco, Colegiado de Farmácia, Petrolina, PE, Brasil.
  • Sá MVS; Universidade Federal do Vale do São Francisco, Colegiado de Farmácia, Petrolina, PE, Brasil.
  • Souza CDF; Universidade Federal de Alagoas, Programa de Pós-graduação em Saúde da Família, Maceió, Brasil.
  • Armstrong ADC; Universidade Federal do Vale do São Francisco, Colegiado de Medicina, Petrolina, PE, Brasil.
  • Carmo RFD; Universidade Federal do Vale do São Francisco, Programa de Pós-graduação em Ciências da Saúde e Biológicas, Petrolina, PE, Brasil.
Rev Soc Bras Med Trop ; 55: e0119, 2022.
Article em En | MEDLINE | ID: mdl-36169489
BACKGROUND: Although most coronavirus disease 2019 (COVID-19) infections are mild, some patients have severe clinical conditions requiring hospitalization. Data on the severity of COVID-19 in Brazil are scarce and are limited to public databases. This study aimed to investigate the clinical and laboratory factors associated with the severity of COVID-19 in a cohort of hospitalized adults from two hospitals in Northeast Brazil. METHODS: Patients over 18 years of age who were hospitalized between August 2020 and July 2021 with a confirmed diagnosis of COVID-19 were included. The patients were classified into two groups: moderate and severe. Clinical, laboratory and imaging parameters were collected and compared between the groups. A multivariate logistic regression model was used to determine the predictors of COVID-19 severity. RESULTS: This study included 495 patients (253 moderate and 242 severe). A total of 372 patients (75.2%) were between 18 and 65 years of age, and the majority were male (60.6%; n = 300). Patients with severe disease had higher levels of leukocytes, neutrophils, platelets, neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, blood glucose, C-reactive protein, ferritin, D-dimer, aspartate aminotransferase, creatinine, and urea (p < 0.05). In multivariate logistic regression, the following variables were significant predictors of COVID-19 severity: leukocytes (odds ratio [OR] 3.27; 95% confidence interval [CI] 2.12-5.06), international normalized ratio (INR) (OR 0.22, 95% CI 0.14-0.33), and urea (OR 4.03; 95% CI 2.21-7.35). CONCLUSIONS: The present study identified the clinical and laboratory factors associated with the severity of COVID-19 in hospitalized Brazilian individuals.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev Soc Bras Med Trop Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev Soc Bras Med Trop Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil