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Association between the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants with vitiligo: study on a Mexican population.
Salinas-Santander, Mauricio Andrés; Suárez-Valencia, Víctor de Jesús; Ángel-Martínez, Mayela Del; Kubelis-Lopez, David Emmanuel; Zapata-Salazar, Natalia Aranza; Ocampo-Garza, Jorge Alejandro; Ocampo-Candiani, Jorge.
Afiliação
  • Salinas-Santander MA; Research Department, Facultad de Medicina Unidad Saltillo, Universidad Autónoma de Coahuila, Saltillo, Coahuila, Mexico. Electronic address: msalinsa@yahoo.com.
  • Suárez-Valencia VJ; Research Department, Facultad de Medicina Unidad Saltillo, Universidad Autónoma de Coahuila, Saltillo, Coahuila, Mexico.
  • Ángel-Martínez MD; Research Department, Facultad de Medicina Unidad Saltillo, Universidad Autónoma de Coahuila, Saltillo, Coahuila, Mexico.
  • Kubelis-Lopez DE; Dermatology Service, Hospital Universitario Dr José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
  • Zapata-Salazar NA; Dermatology Service, Hospital Universitario Dr José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
  • Ocampo-Garza JA; Dermatology Service, Hospital Universitario Dr José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
  • Ocampo-Candiani J; Dermatology Service, Hospital Universitario Dr José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
An Bras Dermatol ; 97(6): 710-715, 2022.
Article em En | MEDLINE | ID: mdl-36163113
BACKGROUND: Vitiligo is characterized by an autoimmune response targeting melanocytes, thus resulting in skin depigmentation. There are several genetic components involved in the development of vitiligo, of which various gene polymorphisms are currently considered as risk factors. For example, the CTLA4 (T-lymphocyte antigen 4) +49A/G (rs231775) and CT60 (rs3087243) gene variants have been associated with a predisposition for autoimmune diseases in different populations; however, their involvement in the development of vitiligo remains controversial. OBJECTIVE: We evaluated the association between vitiligo and the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants in a Mexican population. METHODS: A total of 116 vitiligo patients and 117 control subjects from northeast Mexico were included in the study and analyzed through PCR-RFLP to determine whether there is an association between vitiligo and CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants. RESULTS: No statistical difference was observed for both gene polymorphisms between vitiligo patients and controls (p > 0.05). Otherwise, vitiligo activity, family history of vitiligo, personal history of autoimmune diseases, or sex did not show any difference (p > 0.05). CONCLUSION: As suggested by the analysis of a northeastern Mexican population, the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants do not constitute a risk factor in the development of vitiligo.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Vitiligo / Hipopigmentação Tipo de estudo: Observational_studies Limite: Humans País/Região como assunto: Mexico Idioma: En Revista: An Bras Dermatol Ano de publicação: 2022 Tipo de documento: Article País de publicação: Espanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Vitiligo / Hipopigmentação Tipo de estudo: Observational_studies Limite: Humans País/Região como assunto: Mexico Idioma: En Revista: An Bras Dermatol Ano de publicação: 2022 Tipo de documento: Article País de publicação: Espanha