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Oxidative stress, ceruloplasmin and neopterin biomarkers in dromedary camels with clinical endometritis.
El-Deeb, Wael; Abdelghani, Mohammed Ali; Alhaider, Abdulrahman; Fayez, Mahmoud.
Afiliação
  • El-Deeb W; Al Bilad Bank Scholarly Chair for Food Security in Saudi Arabia, Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, Al Ahsa, Saudi Arabia.
  • Abdelghani MA; Department of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
  • Alhaider A; Department of Internal Medicine, Infectious Diseases and Fish Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
  • Fayez M; Al Bilad Bank Scholarly Chair for Food Security in Saudi Arabia, Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, Al Ahsa, Saudi Arabia.
Anim Reprod ; 19(3): e20220035, 2022.
Article em En | MEDLINE | ID: mdl-36156882
The purpose of this study is to investigate the role of some oxidative stress (OS), ceruloplasmin (Cp), and neopterin (NPT) as diagnostic biomarkers for dromedary camels endometritis as well as to explore the impact of ceftiofur treatment on endometritis. Camels were categorized into two groups; healthy control group (n = 20) and endometritis group (n = 60). She-camels with clinical signs of endometritis (CE) received 6.6 mg/kg BW of ceftiofur (i/m). On days 7, and 14, she-camels were evaluated and clinical cure or failure to cure was determined. The comparison of the groups for OS demonstrated that endometritis caused an increase in serum malondialdehyde (sMDA), Cp, and NPT levels (P<0.05), but decreased serum levels of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) (P<0.05). The most prevalent pathogens involved in the etiology of CE are Arcanobacterium pyogenes, Streptococcus pyogenes, and Staphylococcus aureus. All examined biomarkers demonstrated a high degree of recognition between CE camel and healthy controls (the area under the curve (AUC) was 95.9 for NPT). A higher proportion of camels with CE that were treated with ceftiofur (90%, P<0.0001) showed clinical cure by the first dose, while 10% required a second dose. In conclusion, CE causes increased oxidative reactions and decreased antioxidant defense competence. Subsequently, the alteration in that balance that was represented by the biomarkers of OS could be beneficial for clinical practice and basic clinical research. Additionally, all trials demonstrated the efficacy of ceftiofur for the treatment of CE in she-camel.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Anim Reprod Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Arábia Saudita País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Anim Reprod Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Arábia Saudita País de publicação: Brasil