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Interleukin-17A in Egyptian leprosy patients: a clinical, genetic, and biochemical study.
Farag, Azza Gaber Antar; Labeeb, Azza Zagloul; Gerges, Amany Nagy Abdalla; Elshaib, Mustafa Elsayed.
Afiliação
  • Farag AGA; Dermatology, Andrology and STDs Department, Faculty of Medicine, Menoufia University, Egypt. Electronic address: azzagaber92@yahoo.com.
  • Labeeb AZ; Microbiology and Immunology Department, Faculty of Medicine, Menoufia University, Egypt.
  • Gerges ANA; Leprosy and Dermatology Clinic, Ministry of Health, Shebin Elkoom Teaching Hospital, Egypt.
  • Elshaib ME; Medical Student, Faculty of Medicine, Menoufia University, Egypt.
An Bras Dermatol ; 97(6): 735-741, 2022.
Article em En | MEDLINE | ID: mdl-36153175
BACKGROUND: Leprosy represents a long-term communicable disease resulting from Mycobacterium leprae infection. IL-17A is one of the pro-inflammatory cytokines that protects humans against many fungal and bacterial pathogens. OBJECTIVE: To investigate IL-17A (rs2275913) gene polymorphism and its circulating level in leprosy patients, and to correlate the detected results with different clinical aspects of leprosy in the investigated patients. METHODS: 60 patients with leprosy, and 29 age and sex-matched volunteers were investigated for IL-17A serum level and IL-17A single nucleotide polymorphism (SNP) by ELISA and RFLP-PCR respectively. RESULTS: IL-17A serum level was significantly higher in leprosy patients than in controls (p=0.034), and in TL than LL (p=0.017). IL-17A (rs2275913 A/G) G allele and GG genotype were associated significantly with LL (p=0.005and 0.001 respectively). IL-17A (rs2275913 A/G) AG genotype carriers demonstrated the highest IL-17A serum levels; however, its lowest levels were found in IL-17A (rs2275913 A/G) AA genotype carriers (p=0.005). Grade 2 disability (p=0.030) and positive slit skin smear (SSS) (p=0.005) were significantly associated with IL-17A (rs2275913 A/G) GG genotype. STUDY LIMITATIONS: The small number of studied subjects. CONCLUSIONS: IL -17A may have a pivotal role in leprosy pathogenesis. IL-17A (rs2275913) GG genotype plus G allele might be related to the development of LL in the Egyptian population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Interleucina-17 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Africa Idioma: En Revista: An Bras Dermatol Ano de publicação: 2022 Tipo de documento: Article País de publicação: Espanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Interleucina-17 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Africa Idioma: En Revista: An Bras Dermatol Ano de publicação: 2022 Tipo de documento: Article País de publicação: Espanha