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Exposure to polystyrene nanoplastics induces an anxiolytic-like effect, changes in antipredator defensive response, and DNA damage in Swiss mice.
Guimarães, Abraão Tiago Batista; Freitas, Ítalo Nascimento; Mubarak, Nabisab Mujawar; Rahman, Md Mostafizur; Rodrigues, Fernando Postalli; Rodrigues, Aline Sueli de Lima; Barceló, Damià; Islam, Abu Reza Md Towfiqul; Malafaia, Guilherme.
Afiliação
  • Guimarães ATB; Laboratory of Toxicology Applied to the Environment, Goiano Federal Institute, Urutaí, GO, Brazil.
  • Freitas ÍN; Laboratory of Toxicology Applied to the Environment, Goiano Federal Institute, Urutaí, GO, Brazil; Post-Graduation Program in Ecology, Conservation, and Biodiversity, Federal University of Uberlândia, Uberlândia, MG, Brazil.
  • Mubarak NM; Petroleum and Chemical Engineering, Faculty of Engineering, Universiti Teknologi Brunei, Bandar Seri Begawan BE1410, Brunei Darussalam.
  • Rahman MM; Laboratory of Environmental Health and Ecotoxicology, Department of Environmental Sciences, Jahangirnagar University, Dhaka 1342, Bangladesh.
  • Rodrigues FP; Laboratory of Toxicology Applied to the Environment, Goiano Federal Institute, Urutaí, GO, Brazil.
  • Rodrigues ASL; Post-Graduation Program in Conservation of Cerrado Natural Resources, Goiano Federal Institute, Urutaí, GO, Brazil.
  • Barceló D; Catalan Institute for Water Research (ICRA-CERCA), H2O Building, Scientific and Technological Park of the University of Girona, Emili Grahit 101, 17003, Girona, Spain; Water and Soil Quality Research Group, Department of Environmental Chemistry, Institute of Environmental Assessment and Water Resear
  • Islam ARMT; Begum Rokeya University, Department of Disaster Management, Rangpur, Bangladesh.
  • Malafaia G; Laboratory of Toxicology Applied to the Environment, Goiano Federal Institute, Urutaí, GO, Brazil; Post-Graduation Program in Conservation of Cerrado Natural Resources, Goiano Federal Institute, Urutaí, GO, Brazil; Post-Graduation Program in Ecology, Conservation, and Biodiversity, Federal Universit
J Hazard Mater ; 442: 130004, 2023 01 15.
Article em En | MEDLINE | ID: mdl-36152541
Although the in vivo toxicity of nanoplastics (NPs) has already been reported in different model systems, their effects on mammalian behavior are poorly understood. Thus, we aimed to evaluate whether exposure to polystyrene (PS) NPs (diameter: 23.03 ± 0.266 nm) alters the behavior (locomotor, anxiety-like and antipredator) of male Swiss mice, induces brain antioxidant activity, and erythrocyte DNA damage. For this, the animals were exposed to NPs for 20 days at different doses (6.5 ng/kg and 6500 ng/kg). Initially, we did not observe any effect of pollutants on the locomotor activity of the animals (inferred via open field test and Basso mouse scale for locomotion). However, we noticed an anxiolytic-like behavior (in the open field test) and alterations in the antipredatory defensive response of mice exposed to PS NPs, when confronted with their predator potential (snake, Pantherophis guttatus). Furthermore, such changes were associated with suppressing brain antioxidant activity, inferred by lower DPPH radical scavenging activity, reduced total glutathione content, as well as the translocation and accumulation of NPs in the brain of the animals. In addition, we noted that the treatments induced DNA damage, evaluated via a single-cell gel electrophoresis assay (comet assay) applied to circulating erythrocytes of the animals. However, we did not observe a dose-response effect for all biomarkers evaluated and the estimated accumulation of PS NPs in the brain. The values of the integrated biomarker response index and the results of the principal component analysis (PCA) and the hierarchical clustering analysis confirmed the similarity between the responses of animals exposed to different doses of PS NPs. Therefore, our study sheds light on how PS NPs can impact mammals and reinforce the ecotoxicological risk associated with the dispersion of these pollutants in natural environments and their uptake by mammals.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiolíticos / Poluentes Químicos da Água / Poluentes Ambientais / Nanopartículas Limite: Animals Idioma: En Revista: J Hazard Mater Assunto da revista: SAUDE AMBIENTAL Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiolíticos / Poluentes Químicos da Água / Poluentes Ambientais / Nanopartículas Limite: Animals Idioma: En Revista: J Hazard Mater Assunto da revista: SAUDE AMBIENTAL Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda