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Wound healing in weaning, adult, and old rats with provoked incisional hernias. A comparative study.
Amaral, Raphael Nogueira do; Tannuri, Ana Cristina Aoun; Neri, Junia Marielle Teixeira Rodrigues; Reis, Hugo de Souza; Gonçalves, Josiane Oliveira; Serafini, Suellen; Tannuri, Uenis.
Afiliação
  • Amaral RND; Medical Researcher, Pediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
  • Tannuri ACA; Professor, Pediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
  • Neri JMTR; Medical Researcher, Pediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
  • Reis HS; Pediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
  • Gonçalves JO; Biologist, Pediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
  • Serafini S; Biologist, Pediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
  • Tannuri U; Head Professor, Pediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address: uenist@usp.br.
Clinics (Sao Paulo) ; 77: 100106, 2022.
Article em En | MEDLINE | ID: mdl-36137344
BACKGROUND: Incisional hernias are more frequent in adults than in children. It is hypothesized that a more efficient healing process in pediatric patients could explain this difference in incidence. Certain elements of healing such as neovascularization, degree of inflammation, percentage of mature and immature collagen, the proliferation of fibroblasts, and expression of certain genes could explain why healing in children is more efficient when compared to the adult and elderly populations. MATERIALS AND METHODS: Seventy-one rats of 3 different age groups (weaning, adult, and old) underwent surgery with 3 different incisions (vertical, oblique, and horizontal). During the procedure, the skin and abdominal wall of the animal were sectioned and only the skin was sutured to mimic incisional hernia in the animals. Four weeks after surgery, the rats were euthanized, their skin was removed, and the extent of scar tissue formed in the muscle opening was measured. In addition, samples of the scar tissue were collected for histological, immunohistochemical, and molecular analyzes. Nine rats served as controls. RESULTS: Shorter-length hernias were formed in weaning rats when compared to old ones when the surgical incision was horizontal (p = 0.03). There was a greater proliferation of fibroblasts in rats in the younger age groups, regardless of the type of incision. The Lox gene was more expressed in weaning rats with vertical and oblique incisions. CONCLUSIONS: These differences could explain the better healing and lower incidence of hernias in the pediatric population, although this aspect requires further studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hérnia Incisional Limite: Animals / Child / Humans Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hérnia Incisional Limite: Animals / Child / Humans Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos