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Evaluation of a New Porcine Bone Graft on the Repair of Surgically Created Critical Bone Defects in Rat Calvaria: Histomorphometric and Microtomographic Study.
Fernandes, Ytalo; Mantovani, Rafael; Reino, Danilo; Novaes, Arthur; Messora, Michel; Gustavo Sousa, Luiz; Palioto, Daniela; Scombatti de Souza, Sergio.
Afiliação
  • Fernandes Y; Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto 14040-904, SP, Brazil.
  • Mantovani R; Department of Basic and Oral Biology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14040-904, SP, Brazil.
  • Reino D; Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto 14040-904, SP, Brazil.
  • Novaes A; Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto 14040-904, SP, Brazil.
  • Messora M; Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto 14040-904, SP, Brazil.
  • Gustavo Sousa L; Department of Basic and Oral Biology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14040-904, SP, Brazil.
  • Palioto D; Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto 14040-904, SP, Brazil.
  • Scombatti de Souza S; Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto 14040-904, SP, Brazil.
J Funct Biomater ; 13(3)2022 Aug 23.
Article em En | MEDLINE | ID: mdl-36135558
The aim of this study was to evaluate the use of a new porcine bone graft in rat calvaria bone defects. Critical defects were surgically created in 24 rats that were divided into four experimental groups according to defect filling (n = 6): Control Group (CG)­blood clot; Porcine Bone Group (PG)­porcine-derived bone substitute; (BG): Bio-Oss Group (BG)−chemically and heat-treated bovine graft; Bonefill Group (BFG)­chemically treated bovine bone substitute. Euthanasia of the animals occurred 30 days after the surgery, and the area of the original surgical defect and the surrounding tissues were removed for micro-CT and histomorphometric analysis. In the micro-CT evaluation, the PG presented statistically significant differences (p < 0.05) in comparison to the CG, BG and BFG, for the parameters percentage of Bone Volume (BV/TV), Surface Bone Density (BS/TV), Number of Trabeculae (Tb.N) and Bone Connectivity (Conn), but not for Total Porosity (Po.tot) and Trabecular Thickness (Tb.Th). The histomorphometric analysis showed that the PG presented similar results to the BG regarding newly formed bone extension and to the BG and BFG regarding newly formed bone area. The porcine-derived graft presented superior microtomographic and histomorphometric results when compared to the two bovine bone substitutes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Funct Biomater Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Funct Biomater Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça