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Simulated gastrointestinal digestion/Caco-2 cell model to predict bioaccessibility and intestinal permeability of p-coumaric acid and p-coumaroyl derivatives in peanut.
Prado Massarioli, Adna; Giovanini de Oliveira Sartori, Alan; Francetto Juliano, Fernanda; Eduardo Pedroso Gomes do Amaral, José; Cavalcanti Dos Santos, Roseane; Maria de Lima, Liziane; Matias de Alencar, Severino.
Afiliação
  • Prado Massarioli A; Department of Agri-food Industry, Food and Nutrition, Luiz de Queiroz" College of Agriculture, University of São Paulo, São Paulo, SP, Brazil.
  • Giovanini de Oliveira Sartori A; Department of Agri-food Industry, Food and Nutrition, Luiz de Queiroz" College of Agriculture, University of São Paulo, São Paulo, SP, Brazil. Electronic address: alangosartori@usp.br.
  • Francetto Juliano F; Department of Agri-food Industry, Food and Nutrition, Luiz de Queiroz" College of Agriculture, University of São Paulo, São Paulo, SP, Brazil.
  • Eduardo Pedroso Gomes do Amaral J; Department of Agri-food Industry, Food and Nutrition, Luiz de Queiroz" College of Agriculture, University of São Paulo, São Paulo, SP, Brazil.
  • Cavalcanti Dos Santos R; Brazilian Agricultural Research Corporation (Embrapa Algodão), Campina Grande, PB, Brazil.
  • Maria de Lima L; Brazilian Agricultural Research Corporation (Embrapa Algodão), Campina Grande, PB, Brazil.
  • Matias de Alencar S; Department of Agri-food Industry, Food and Nutrition, Luiz de Queiroz" College of Agriculture, University of São Paulo, São Paulo, SP, Brazil. Electronic address: smalencar@usp.br.
Food Chem ; 400: 134033, 2023 Jan 30.
Article em En | MEDLINE | ID: mdl-36084590
Data concerning physiological recovery of whole peanut major phenolics throughout the gastrointestinal tract are scarce. In our study, the bioaccessibility and intestinal permeability of peanuts major phenolics were predicted by simulated digestion followed by Caco-2 cells monolayer model. Phenolics identification and quantification were performed by HPLC-ESI-QTOF-MS and HPLC-PDA, respectively. As results, p-coumaroyl conjugates with tartaric, sinapic and ferulic acids, and p-coumaric acid were the major phenolics found in the non-digested extract and in the digested and transported fractions. The in vitro bioaccessibility and Caco-2 cell transport of p-coumaric acid was 370% and 127%, respectively, while it was much lower for p-coumaroyl derivatives (7-100% and 14-31%, respectively). Nonetheless, the peroxyl scavenging activity remained unaltered, likely, at least partly, due to synergies between some phenolics, which concentration proportions changed throughout the experiment. Hence, there is indication that whole peanut is a source of bioavailable antioxidant phenolics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arachis / Antioxidantes Limite: Humans Idioma: En Revista: Food Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arachis / Antioxidantes Limite: Humans Idioma: En Revista: Food Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido