Adverse effect of 1,25-dihydroxycholecalciferol on erythrocyte precursors in the rat.
Acta Physiol Pharmacol Latinoam
; 36(4): 397-402, 1986.
Article
em En
| MEDLINE
| ID: mdl-3604704
Administration of 1,25-dihydroxycholecalciferol (0.5 microgram/d/100 g body weight) to vitamin D repleted rats produced a significant decrease in the number of femoral marrow cells, specially in the erythroid line. Analysis of blood revealed slight anemia with reticulocytopenia. The survival time of 51-Cr-labelled red cells was unaffected by treatment, suggesting that bone marrow became unable to replace cells at a normal rate. The adverse effect on erythropoiesis appeared related to the degree of the concurrent hypercalcemia, which in turn depends upon the calcium content of the diet.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reticulócitos
/
Calcitriol
/
Cálcio
/
Eritropoese
Limite:
Animals
Idioma:
En
Revista:
Acta Physiol Pharmacol Latinoam
Assunto da revista:
FARMACOLOGIA
/
FISIOLOGIA
Ano de publicação:
1986
Tipo de documento:
Article
País de publicação:
Argentina