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Dynamic coupling between the central and autonomic cardiac nervous systems in patients with refractory epilepsy: A pilot study.
Melo, Eline; Fiel, José; Milhomens, Rodrigo; Ribeiro, Thaynara; Navegantes, Raphael; Gomes, Francinaldo; Duarte Gomes, Bruno; Pereira, Antonio.
Afiliação
  • Melo E; Graduate Program in Neuroscience and Cell Biology, Federal University of Pará, Belém, Brazil.
  • Fiel J; Graduate Program in Electrical Engineering, Federal University of Pará, Belém, Brazil.
  • Milhomens R; Department of Electrical and Biomedical Engineering, Institute of Technology, Belém, Brazil.
  • Ribeiro T; Department of Electrical and Biomedical Engineering, Institute of Technology, Belém, Brazil.
  • Navegantes R; Graduate Program in Electrical Engineering, Federal University of Pará, Belém, Brazil.
  • Gomes F; Hospital Ophir Loyola, Belém, Brazil.
  • Duarte Gomes B; Graduate Program in Neuroscience and Cell Biology, Federal University of Pará, Belém, Brazil.
  • Pereira A; Department of Biotechnology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Front Neurol ; 13: 904052, 2022.
Article em En | MEDLINE | ID: mdl-36034270
The heart and brain are reciprocally interconnected and engage in two-way communication for homeostatic regulation. Epilepsy is considered a network disease that also affects the autonomic nervous system (ANS). The neurovisceral integration model (NVM) proposes that cardiac vagal tone, indexed by heart rate variability (HRV), can indicate the functional integrity of cognitive neural networks. ANS activity and the pattern of oscillatory EEG activity covary during the transition of arousal states and associations between cortical and autonomic activity are reflected by HRV. Cognitive dysfunction is one of the common comorbidities that occur in epilepsy, including memory, attention, and processing difficulties. Recent studies have shown evidence for the active involvement of alpha activity in cognitive processes through its active role in the control of neural excitability in the cortex through top-down modulation of cortical networks. In the present pilot study, we evaluated the association between resting EEG oscillatory behavior and ANS function in patients with refractory epilepsy. Our results show: (1) In patients with refractory epilepsy, there is a strong positive correlation between HRV and the power of cortical oscillatory cortical activity in all studied EEG bands (delta, theta, alpha, and beta) in all regions of interest in both hemispheres, the opposite pattern found in controls which had low or negative correlation between these variables; (2) higher heartbeat evoked potential amplitudes in patients with refractory epilepsy than in controls. Taken together, these results point to a significant alteration in heart-brain interaction in patients with refractory epilepsy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Neurol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Neurol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça