Odorant receptors as potential drug targets.

Naressi, Rafaella G; Schechtman, Deborah; Malnic, Bettina

Naressi, Rafaella G; Schechtman, Deborah; Malnic, Bettina.

Afiliação

Naressi RG; Department of Biochemistry, University of São Paulo, São Paulo, Brazil.
Schechtman D; Department of Biochemistry, University of São Paulo, São Paulo, Brazil.
Malnic B; Department of Biochemistry, University of São Paulo, São Paulo, Brazil. Electronic address: bmalnic@iq.usp.br.

Trends Pharmacol Sci ; 44(1): 11-14, 2023 01.

Article em En | MEDLINE | ID: mdl-35999088

RESUMO

Odorant receptors (ORs) belong to a large family of G protein-coupled receptors (GPCRs) that are highly expressed by olfactory sensory neurons of the nose. Accumulating evidence indicates that they are also expressed in a variety of nonolfactory tissues, which makes them new potential drug targets. Here we discuss the challenges and strategies to target these receptors.

Assuntos

Neurônios Receptores Olfatórios; Receptores Odorantes; Humanos; Receptores Acoplados a Proteínas G

Palavras-chave

GPCRs; drug; ectopic; odorant receptors; target

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Odorantes / Neurônios Receptores Olfatórios Limite: Humans Idioma: En Revista: Trends Pharmacol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

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