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Cetyltrimethylammonium bromide in the synthesis of mesoporous silica nanoparticles: General aspects and in vitro toxicity.
Carvalho, Gabriela Corrêa; Marena, Gabriel Davi; Karnopp, Juliana Camila Fischer; Jorge, Juliana; Sábio, Rafael Miguel; Martines, Marco Antonio Utrera; Bauab, Taís Maria; Chorilli, Marlus.
Afiliação
  • Carvalho GC; School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, Brazil.
  • Marena GD; School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, Brazil.
  • Karnopp JCF; Institute of Chemistry, Federal University of Mato Grosso do Sul (UFMS), 79070-90 Campo Grande, Brazil.
  • Jorge J; Institute of Chemistry, Federal University of Mato Grosso do Sul (UFMS), 79070-90 Campo Grande, Brazil.
  • Sábio RM; School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, Brazil.
  • Martines MAU; Institute of Chemistry, Federal University of Mato Grosso do Sul (UFMS), 79070-90 Campo Grande, Brazil.
  • Bauab TM; School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, Brazil.
  • Chorilli M; School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, Brazil. Electronic address: marlus.chorilli@unesp.br.
Adv Colloid Interface Sci ; 307: 102746, 2022 Sep.
Article em En | MEDLINE | ID: mdl-35969965
Pharmaceutical nanotechnology has become a trend with incalculable advantages in the applicability of systems in the controlled, safe and effective release of drugs. Among the nanotechnological nanoparticles, the mesoporous silica nanoparticles stand out, a system with significant biocompatibility, good physical chemical stability, greater surface contact area with desirable and adjustable pore structure. Once developed and well defined, these pores can carry drugs and control their release. However, to create this type of nanoparticle is essencial to use surfactants since they act as pore template. Among the most important surfactants, cetyltrimethylammonium bromide (CTAB) highlights, a quaternary ammonium compound widely used as a surfactant in the synthesis of mesoporous silica nanoparticles (MSNs), hollow mesoporous silica (HMSNs) and core-shell MSNs. However, for achieving good results of drug-loaded pores it is necessary to remove CTAB by extraction techniques, which provides pores formation throughout the silica and the incorporation of molecules. During and after the removal process, it is possible that CTAB residues remains inside the pores, despide several removal processes are described as efficient in the complete removal of surfactants. In turn, the presence of CTAB residues can be advantageous, especially when considering its antimicrobial activity. Meanwhile, it should be noted that the presence of CTAB may present high toxicity risks. This review seeks to explore not only general aspects of the use of CTAB in the synthesis of MSNs, but also to assess its toxicity in prokaryotic and eukaryotic cells, in order to determine whether CTAB residues are acceptable in MSNs that will be used as drug delivery systems for further in vivo and clinical assays.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dióxido de Silício / Nanopartículas Idioma: En Revista: Adv Colloid Interface Sci Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dióxido de Silício / Nanopartículas Idioma: En Revista: Adv Colloid Interface Sci Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda