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Pre-clinical evidence for the therapeutic effect of Pitaya (Hylocereus lemairei) on diabetic intestinal microenvironment.
Lodi, Karina Zanella; Cappelari, Monique Brigolini; Pilatti, Gabriela Carolina; Fontana, Roselei Claudete; Camassola, Marli; Salvador, Mirian; Branco, Catia Santos.
Afiliação
  • Lodi KZ; Laboratory of Oxidative Stress and Antioxidants, Biotechnology Institute, University of Caxias do Sul, Caxias do Sul, Brazil.
  • Cappelari MB; Department of Life Sciences, University of Caxias do Sul, Caxias do Sul, Brazil.
  • Pilatti GC; Department of Life Sciences, University of Caxias do Sul, Caxias do Sul, Brazil.
  • Fontana RC; Laboratory of Enzymes and Biomass, Biotechnology Institute, University of Caxias do Sul, Caxias do Sul, Brazil.
  • Camassola M; Laboratory of Enzymes and Biomass, Biotechnology Institute, University of Caxias do Sul, Caxias do Sul, Brazil.
  • Salvador M; Laboratory of Oxidative Stress and Antioxidants, Biotechnology Institute, University of Caxias do Sul, Caxias do Sul, Brazil.
  • Branco CS; Laboratory of Oxidative Stress and Antioxidants, Biotechnology Institute, University of Caxias do Sul, Caxias do Sul, Brazil.
Nat Prod Res ; 37(10): 1735-1741, 2023 May.
Article em En | MEDLINE | ID: mdl-35945808
Intestinal glucose absorption plays a central role in the regulation of glucose plasmatic; however, current clinical management does not target the gut for treating diabetes. This study evaluated the effects of peel and pulp aqueous extract from Hylocereus lemairei on human enterocytes under high glucose concentration. Anti-hyperglycemic and antiobesity activities in vitro were also evaluated. Extracts did not cause cytotoxicity at 1 to 500 µg/mL. Moreover, they were effective in attenuating oxidative stress (DCFH-DA assay) and inflammation (•ON production) caused by high glucose. Intestinal enzymes (α- glucosidase and pancreatic lipase) were inhibited by pulp and peel extracts (>60% and >95%, respectively). Extracts exhibited a redox capacity superior to ascorbic and chlorogenic acids, presenting high phenolic content, mainly anthocyanins. The main compounds for both extracts were chlorogenic acid and naringin, and peel stood both qualitatively and quantitatively. Data suggest red Pitaya has potential as a new medicine for diabetes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Antocianinas Limite: Humans Idioma: En Revista: Nat Prod Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Antocianinas Limite: Humans Idioma: En Revista: Nat Prod Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido