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Clinical Significance of Early Pulmonary Hypertension in Preterm Infants.
Arjaans, Sanne; Fries, Marian W F; Schoots, Mirthe H; Schilte, Carine F M; Roofthooft, Marc T R; Vrijlandt, Elianne J L E; Bos, Arie F; Kooi, Elisabeth M W; Berger, Rolf M F.
Afiliação
  • Arjaans S; Department of Pediatric Cardiology, University of Groningen, University Medical Center Groningen, Center for Congenital Heart Diseases, Beatrix Children's Hospital, Groningen, The Netherlands. Electronic address: s.arjaans@umcg.nl.
  • Fries MWF; Department of Pediatric Cardiology, University of Groningen, University Medical Center Groningen, Center for Congenital Heart Diseases, Beatrix Children's Hospital, Groningen, The Netherlands.
  • Schoots MH; Department of Pathology & Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Schilte CFM; Department of Pediatric Cardiology, University of Groningen, University Medical Center Groningen, Center for Congenital Heart Diseases, Beatrix Children's Hospital, Groningen, The Netherlands; Department of Neonatology, University of Groningen, University Medical Center Groningen, Beatrix Children's
  • Roofthooft MTR; Department of Pediatric Cardiology, University of Groningen, University Medical Center Groningen, Center for Congenital Heart Diseases, Beatrix Children's Hospital, Groningen, The Netherlands.
  • Vrijlandt EJLE; Department of Pediatric Pulmonology & Allergology, University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Groningen, The Netherlands.
  • Bos AF; Department of Neonatology, University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Groningen, The Netherlands.
  • Kooi EMW; Department of Neonatology, University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Groningen, The Netherlands.
  • Berger RMF; Department of Pediatric Cardiology, University of Groningen, University Medical Center Groningen, Center for Congenital Heart Diseases, Beatrix Children's Hospital, Groningen, The Netherlands.
J Pediatr ; 251: 74-81.e3, 2022 12.
Article em En | MEDLINE | ID: mdl-35934129
OBJECTIVE: To characterize different phenotypes of early pulmonary hypertension (PH) in preterm infants and their respective associations with bronchopulmonary dysplasia (BPD) and survival. STUDY DESIGN: A prospective cohort study in a tertiary university medical center from June 2016 until March 2019. Infants with a gestational age <30 weeks and/or a birth weight <1000 g were included. Echocardiographic assessment for PH was performed at 3-10 days after birth. Subsequent development of BPD at 36 weeks postmenstrual age and mortality were assessed. RESULTS: Early PH was identified in 55% of 104 included infants, including 21% with persistent PH of the newborn (PPHN), 61% with flow-associated PH, and 18% PH without shunt. Only PPHN was associated with placental fetal vascular malperfusion, lower gestational age, and low Apgar score. Both PPHN and flow PH were associated with the development of BPD. Early PH was associated with poorer survival, driven by PPHN. CONCLUSIONS: Early PH is highly prevalent (55%) in preterm infants and associated with the development of BPD, independent of the phenotype of PH. Infants with PPHN had the poorest survival. Early PH presents in various phenotypes characterized by differences in etiology, pathophysiology, and associated long-term sequelae.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Displasia Broncopulmonar / Hipertensão Pulmonar Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: J Pediatr Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Displasia Broncopulmonar / Hipertensão Pulmonar Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: J Pediatr Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos