Your browser doesn't support javascript.
loading
Radiation-induced Sarcoma in the Head and Neck: Clinical, Imaging, Histopathological, and Therapeutic Characterization.
Bernaola-Paredes, Wilber Edison; Filippetti, Eloah Pascuotte; Rodrigues, Monica Lucia; Carvalho, Henrique Perez; Coutinho, Marcelo Carvalho; Arruda, Arthur Ferrari; Pinto, Pedro Jorge Joffily; Costa, Felipe D'Almeida; Celestino, Miriã Andrade; Pellizzon, Antonio Cassio Assis.
Afiliação
  • Bernaola-Paredes WE; Department of Radiation Oncology, A.C. Camargo Cancer Center, São Paulo, Brazil.
  • Filippetti EP; Department of Radiation Oncology, A.C. Camargo Cancer Center, São Paulo, Brazil.
  • Rodrigues ML; Department of Head and Neck Surgery & Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil.
  • Carvalho HP; Department of Head and Neck Surgery & Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil.
  • Coutinho MC; Department of Head and Neck Surgery & Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil.
  • Arruda AF; Department of Anatomic Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil.
  • Pinto PJJ; Department of Radiation Oncology, A.C. Camargo Cancer Center, São Paulo, Brazil.
  • Costa FD; Department of Anatomic Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil.
  • Celestino MA; Department of Stomatology, School of Dentistry, University Center "UNIFAMINAS," Muriaé, Minas Gerais, Brazil.
  • Pellizzon ACA; Department of Radiation Oncology, A.C. Camargo Cancer Center, São Paulo, Brazil.
Plast Reconstr Surg Glob Open ; 10(7): e4418, 2022 Jul.
Article em En | MEDLINE | ID: mdl-35923999
Radiation-induced head and neck sarcoma (RIHNS) is a rare and serious long-term complication of radiotherapy (RT), with poor prognosis and high morbidity and mortality. Diagnosis is based on immunohistochemistry and molecular biomarker analysis, and therapy is usually surgical. Other adjuvant therapies might be considered. This case report aimed to describe the clinical, imaging, histopathological, and therapeutic characteristics of a rare case of RIHNS in the mandible after 21 years of RT. A 68-year-old male patient underwent a partial left parotidectomy in 1995, was diagnosed with pleomorphic adenoma, and after recurrence of the lesion in 2000, underwent an ipsilateral total parotidectomy with adjuvant RT. In May 2021, he complained of an ulcerated nodular lesion on the tongue that extended toward the lower gingiva, associated with oral bleeding and difficulties with swallowing. After biopsy in the gingival margin and histopathological analysis, the diagnosis of high-grade spindle-cell sarcoma was established. Complete surgical resection with microsurgical reconstruction using a fibular osteomusculocutaneous free flap was performed. RIHNS could appear after a period of almost 20 years after RT. Surgical resection with reconstructive surgery was a reliable and feasible therapeutic option that showed favorable clinical results after an appropriate follow-up.
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Plast Reconstr Surg Glob Open Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Plast Reconstr Surg Glob Open Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos