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Potassium Channels as a Target for Cancer Therapy: Current Perspectives.
Zúñiga, Leandro; Cayo, Angel; González, Wendy; Vilos, Cristian; Zúñiga, Rafael.
Afiliação
  • Zúñiga L; Laboratorio de Fisiología Molecular, Escuela de Medicina, Universidad de Talca, Talca, Chile.
  • Cayo A; Centro de Nanomedicina, Diagnóstico y Desarrollo de Fármacos (ND3), Escuela de Medicina, Universidad de Talca, Talca, Chile.
  • González W; Laboratorio de Fisiología Molecular, Escuela de Medicina, Universidad de Talca, Talca, Chile.
  • Vilos C; Centro de Nanomedicina, Diagnóstico y Desarrollo de Fármacos (ND3), Escuela de Medicina, Universidad de Talca, Talca, Chile.
  • Zúñiga R; Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile.
Onco Targets Ther ; 15: 783-797, 2022.
Article em En | MEDLINE | ID: mdl-35899081
Potassium (K+) channels are highly regulated membrane proteins that control the potassium ion flux and respond to different cellular stimuli. These ion channels are grouped into three major families, Kv (voltage-gated K+ channel), Kir (inwardly rectifying K+ channel) and K2P (two-pore K+ channels), according to the structure, to mediate the K+ currents. In cancer, alterations in K+ channel function can promote the acquisition of the so-called hallmarks of cancer - cell proliferation, resistance to apoptosis, metabolic changes, angiogenesis, and migratory capabilities - emerging as targets for the development of new therapeutic drugs. In this review, we focus our attention on the different K+ channels associated with the most relevant and prevalent cancer types. We summarize our knowledge about the potassium channels structure and function, their cancer dysregulated expression and discuss the K+ channels modulator and the strategies for designing new drugs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Onco Targets Ther Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Chile País de publicação: Nova Zelândia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Onco Targets Ther Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Chile País de publicação: Nova Zelândia