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Zero-Biased Photoelectrochemical Detection of Cardiac Biomarker Myoglobin Based on CdSeS/ZnS Quantum Dots and Barium Titanate Perovskite.
Lima, Fernanda M R; de Menezes, Alan S; Maciel, Adeilton P; Sinfrônio, Francisco S M; Kubota, Lauro T; Damos, Flávio S; Luz, Rita C S.
Afiliação
  • Lima FMR; Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, Brazil.
  • de Menezes AS; Department of Physics, Federal University of Maranhão, São Luís 65080-805, Brazil.
  • Maciel AP; Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, Brazil.
  • Sinfrônio FSM; Department of Electrical Engineering, Federal University of Maranhão, São Luís 65080-805, Brazil.
  • Kubota LT; Institute of Chemistry, State University of Campinas, Campinas 13083-970, Brazil.
  • Damos FS; Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, Brazil.
  • Luz RCS; Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, Brazil.
Molecules ; 27(15)2022 Jul 26.
Article em En | MEDLINE | ID: mdl-35897951
Cardiovascular diseases are considered one of the leading causes of premature mortality of patients worldwide. Therefore, rapid diagnosis of these diseases is crucial to ensure the patient's survival. During a heart attack or severe muscle damage, myoglobin is rapidly released in the body to constitute itself as a precise biomarker of acute myocardial infarction. Thus, we described the photoelectrochemical immunosensor development to detect myoglobin. It was based on fluorine-doped tin oxide modified with CdSeS/ZnSe quantum dots and barium titanate (BTO), designated as CdSeS/ZnSQDS/BTO. It was characterized by scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDX), transmission electron microscopy (TEM), X-ray diffraction (XRD), electrochemical impedance spectroscopy (EIS), and amperometry. The anodic photocurrent at the potential of 0 V (vs. Ag/AgCl) and pH 7.4 was found linearly related to the myoglobin (Mb) concentration from 0.01 to 1000 ng mL-1. Furthermore, the immunosensor showed an average recovery rate of 95.7-110.7% for the determination of myoglobin.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfatos / Técnicas Biossensoriais / Compostos de Selênio / Compostos de Cádmio / Pontos Quânticos Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfatos / Técnicas Biossensoriais / Compostos de Selênio / Compostos de Cádmio / Pontos Quânticos Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça