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Association between coffee consumption with serum lipid profile in ELSA-Brasil study: a metabolomic approach.
Miranda, Andreia Machado; Goulart, Alessandra Carvalho; Generoso, Giuliano; Bittencourt, Márcio Sommer; Santos, Raul Dias; Toth, Peter P; Jones, Stevens R; Benseñor, Isabela M; Lotufo, Paulo A; Marchioni, Dirce Maria.
Afiliação
  • Miranda AM; Department of Nutrition, School of Public Health, University of São Paulo, Sao Paulo, SP, Brazil. andreia.am.miranda@gmail.com.
  • Goulart AC; Departamento de Nutrição, Faculdade de Saúde Pública, University of São Paulo, Av. Dr. Arnaldo, 715, Cerqueira César, São Paulo, SP, 01246-904, Brasil. andreia.am.miranda@gmail.com.
  • Generoso G; Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, Sao Paulo, SP, Brazil.
  • Bittencourt MS; Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, Sao Paulo, SP, Brazil.
  • Santos RD; Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, Sao Paulo, SP, Brazil.
  • Toth PP; Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, Sao Paulo, SP, Brazil.
  • Jones SR; Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil.
  • Benseñor IM; Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, IL, USA.
  • Lotufo PA; Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, IL, USA.
  • Marchioni DM; Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, Sao Paulo, SP, Brazil.
Eur J Nutr ; 61(8): 4205-4214, 2022 Dec.
Article em En | MEDLINE | ID: mdl-35895137
PURPOSE: This study evaluated the association between coffee consumption and serum lipid profile in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). METHODS: This is a cross-sectional study on baseline data from participants of the cohort ELSA-Brasil. Only participants of São Paulo Research Center who underwent a nuclear magnetic resonance (NMR) spectroscopy examination of lipid profile were included (N = 4736). Coffee intake was categorized into four categories (cups/day, in reference cup size of 50 mL, which is the household measure adopted in Brazil): never/almost never, ≤ 1, 1-3, and > 3. Serum lipid profile [i.e., Total Cholesterol (TC), Total Triglycerides (TG), Very Low-Density Lipoprotein-cholesterol (VLDL-c), Low-Density Lipoprotein-cholesterol (LDL-c), High-Density Lipoprotein-cholesterol (HDL-c), Triglyceride-rich Lipoprotein Particles (TRLP) and subfractions particles] was analyzed. To estimate the effect of coffee consumption on serum lipid profile, multivariate Generalized Linear Models were performed. RESULTS: Compared to participants who never or almost never drink coffee, individuals who consumed more than 3 cups/day showed an increase in concentrations of TC (ß: 4.13; 95% CI 0.81, 7.45), TG (ß: 9.53; 95% CI 1.65, 17.42), VLDL-c (ß: 1.90; 95% CI 0.38, 3.42), TRLP (ß: 8.42; 95% CI 1.24, 15.60), and Very Small-TRLP and Medium-TRLP subfractions (ß: 7.36; 95% CI 0.21, 14.51; ß: 2.53; 95% CI 0.89, 4.16, respectively), but not with HDL-c and LDL-c. Among individuals with low (≤ 1 cup/day) and moderate (1-3 cups/day) coffee consumption, no significant associations with lipids was observed. CONCLUSION: High coffee consumption (more than 3 cups per day) was associated with an increase in serum lipids, namely TC, TG, VLDL-c, and TRL particles, highlighting the importance of a moderate consumption of this beverage.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Café Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Eur J Nutr Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Café Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Eur J Nutr Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha