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Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America.
Riera, Fernando Oscar; Caeiro, Juan Pablo; Angiolini, Sofia Carla; Vigezzi, Cecilia; Rodriguez, Emilse; Icely, Paula Alejandra; Sotomayor, Claudia Elena.
Afiliação
  • Riera FO; Division of Infectious Diseases, Sanatorio Allende, Córdoba 5000, Argentina.
  • Caeiro JP; Research Group of Immunology and Mycology, Córdoba 5000, Argentina.
  • Angiolini SC; Research Group of Immunology and Mycology, Córdoba 5000, Argentina.
  • Vigezzi C; Section of Infectious Diseases, Hospital Privado Universitario de Córdoba, Córdoba 5000, Argentina.
  • Rodriguez E; Research Group of Immunology and Mycology, Córdoba 5000, Argentina.
  • Icely PA; Laboratory of Innate Immunity to Fungal Pathogens, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina.
  • Sotomayor CE; CIBICI-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina.
Antibiotics (Basel) ; 11(7)2022 Jun 30.
Article em En | MEDLINE | ID: mdl-35884131
Invasive candidiasis encompassing Candida bloodstream infections and deep-seated candidiasis can become a persistent health problem. These infections are caused by Candida species and have high morbidity and mortality rates. Species distribution, access to diagnosis, treatment and mortality are different around the world. The mortality rate is high in South America (30-70%), and Candida albicans is the most prevalent species in this region. However, a global epidemiological shift to non-albicans species has been observed. In this group, C. parapsilosis is the species most frequently detected, followed by C. tropicalis, and at a slower rate, C. glabrata, which has also increased, in addition to the emerging C. auris, resistance to several drugs. This article summarizes relevant aspects of candidemia pathogenesis, such as the mechanisms of fungal invasion, immune response, and the impact of genetic defects that increase host susceptibility to developing the infection. We also discuss relevant aspects of treatment and future challenges in South America.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Antibiotics (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Antibiotics (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça