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Fever of Unknown Origin, Wasting Syndrome and Bone Marrow Involvement: A Leprosy Case Report.
Santana, Marcela Araujo de Oliveira; da Costa, Willian Vargas Tenório; Celestino, Isadora Costa; Dos Santos, Diogo Fernandes; Dornelas, Bruno de Carvalho; Pavelka, Matthew Martin; Luppi, Andrea De Martino; Goulart, Isabela Maria Bernardes.
Afiliação
  • Santana MAO; National Reference Center for Sanitary Dermatology and Leprosy, Clinics' Hospital, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.
  • da Costa WVT; Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.
  • Celestino IC; Post-Graduation Program in Health Science, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.
  • Dos Santos DF; National Reference Center for Sanitary Dermatology and Leprosy, Clinics' Hospital, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.
  • Dornelas BC; Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.
  • Pavelka MM; Post-Graduation Program in Health Science, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.
  • Luppi AM; Pathology Department, Clinical Hospital, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.
  • Goulart IMB; School of Medicine, Indiana University, Terre Haute, IN, United States.
Front Immunol ; 13: 916319, 2022.
Article em En | MEDLINE | ID: mdl-35874693
Mycobacterium leprae, the etiologic agent of leprosy, is an acid-fast-staining and slow-growing bacilli that infect macrophages and Schwann cells individually or through forming globi. The clinical presentation of leprosy is broad and depends on the host immune response. We report a case of a 42-year-old Brazilian man presenting with fever of unknown origin (FUO), anemia, wasting syndrome, and neuropathy. The diagnosis of lepromatous leprosy was made after an extensive investigation revealed the presence of M. leprae in the bone marrow. Bone marrow involvement in leprosy is rare and some authors believe the presence of M. leprae in the bone marrow can act as a reservoir of the disease facilitating future relapses. It is important to investigate bone marrow involvement in leprosy, especially when the patient presents with cytopenias and positive epidemiologic history.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Emaciação / Febre de Causa Desconhecida / Hanseníase Tipo de estudo: Diagnostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Front Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Emaciação / Febre de Causa Desconhecida / Hanseníase Tipo de estudo: Diagnostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Front Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça