[D. Julius y A. Patapoutian. 2021 Nobel Prize Awardees discover new ionic channels that detect temperature and mechanical stimuli]. / D. Julius y A. Patapoutian. Premios Nobel de Medicina 2021, descubren nuevos canales iónicos que detectan temperatura y estímulos mecánicos.
Rev Med Chil
; 150(1): 88-92, 2022 Jan.
Article
em Es
| MEDLINE
| ID: mdl-35856969
D. Julius was awarded the 2021 Medicine Nobel prize for the discovery of new cationic channels that detect temperatures either over 40 °C (TRPV1) or cold (TRPM8) ranging from 8-15 °C, followed by the latter identification of other channels that sense temperatures within other ranges. On the other hand, A. Patapoutian shared the 2021 Nobel prize for the independent and simultaneous co-discovery of the TRPM8 cationic channel. Furthermore, Patapoutian iden-tified piezo 1 and 2 channels previously referred to as the cell mechanosensors related to the sense of touch and proprioception. These experimental findings indicate that these novel cationic channels localized in nerve endings of the skin, mouth, lips, bronchial tree, the nephron, plus a variety of tissues transduce phy-sical stimuli into electrical activity that reach the brain sensory cortex to process these stimuli and elicit animal behavior.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canais de Cátion TRPM
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Es
Revista:
Rev Med Chil
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Chile