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Genome-wide association study in thoroughbred horses naturally infected with cyathostomins.
Dias De Castro, Luciana L; Oliveira Júnior, Gerson A; Perez, Bruno Costa; Carvalho, Minos E; De Souza Ramos, Edneia A; Ferraz, José Bento S; Molento, Marcelo Beltrão.
Afiliação
  • Dias De Castro LL; Laboratory of Parasitology, Department of Veterinary Medicine, University of Caxias do Sul. R: Francisco Getúlio Vargas, Caxias do Sul, Brazil.
  • Oliveira Júnior GA; College of Animal Science and Food Science, University of São Paulo, Pirassununga, Brazil.
  • Perez BC; Centre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, Canada.
  • Carvalho ME; College of Animal Science and Food Science, University of São Paulo, Pirassununga, Brazil.
  • De Souza Ramos EA; College of Animal Science and Food Science, University of São Paulo, Pirassununga, Brazil.
  • Ferraz JBS; Laboratory of Epigenetics, Department of Pathology, Federal University of Parana, Curitiba, Brazil.
  • Molento MB; College of Animal Science and Food Science, University of São Paulo, Pirassununga, Brazil.
Anim Biotechnol ; 34(7): 2467-2479, 2023 Dec.
Article em En | MEDLINE | ID: mdl-35856721
Cyathostomins are considered one of the most important parasites of horses. A group of horses within a herd can be responsible for eliminating the majority of parasite eggs. This phenotype might be explained by genetic factors. This study aimed to identify genomic regions associated with fecal egg count (FEC) and hematological parameters by performing a genomic-wide association study (GWAS) in Thoroughbred horses naturally infected with cyathostomins. Packed cell volume (PCV), differential leukocyte, and FEC were determined from 90 horses. All animals were genotyped using the Illumina Equine 70 K BeadChip panel containing 65,157 SNP markers. The five genomic windows that have explained the highest percentage of the additive genetic variance of a specific trait (top 5) were further explored to identify candidate genes. A total of 33, 21, 30, 21, and 19 genes were identified for FEC, PCV, eosinophils, neutrophils, and lymphocyte count, respectively. The top 5 marker regions explained 2.86, 2.56, 2.73, 2.33, and 2.37% of the additive genetic variation of FEC, PCV, eosinophils, neutrophils, and lymphocytes count, respectively. This is the first study correlating phenotypic horse health traits to GWAS analysis, which may be used for animal breeding activities, reducing losses due to parasite infections.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genômica / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Anim Biotechnol Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genômica / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Anim Biotechnol Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido