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Treatment of chronic wounds with methylene blue photodynamic therapy: A case report.
Cesar, Gabriel Batista; Winyk, Ana Paula; Sluchensci Dos Santos, Fernando; Queiroz, Erika Fernanda; Soares, Kelly Cristina Nogueira; Caetano, Wilker; Tominaga, Tania Toyomi.
Afiliação
  • Cesar GB; Universidade Estadual do Centro-Oeste (Unicentro), Guarapuava, Brazil.
  • Winyk AP; Universidade Estadual do Centro-Oeste (Unicentro), Guarapuava, Brazil.
  • Sluchensci Dos Santos F; Universidade Estadual do Centro-Oeste (Unicentro), Guarapuava, Brazil.
  • Queiroz EF; Universidade Estadual do Centro-Oeste (Unicentro), Guarapuava, Brazil.
  • Soares KCN; Uniguairacá Centro Universitário, Guarapuava, Brazil.
  • Caetano W; Universidade Estadual de Maringá (UEM), Maringá, Brazil.
  • Tominaga TT; Universidade Estadual do Centro-Oeste (Unicentro), Guarapuava, Brazil. Electronic address: ttominaga@unicentro.br.
Photodiagnosis Photodyn Ther ; 39: 103016, 2022 Sep.
Article em En | MEDLINE | ID: mdl-35840009
Methylene blue (MB) mediated photodynamic therapy (PDT) is an emerging treatment for different kinds of skin lesions and ulcers. Our case report aims to assess its potential in treating diabetic foot ulcers, venous leg ulcers, and pressure ulcers. Patients presented with complex chronic wounds larger than 40 cm2 with low healing potential. Once a week, patients had an aqueous formulation of MB at a concentration of 10 mg/mL (1% w/v) applied topically on their wounds, which were then irradiated with a light-emitting diode (LED) light source (660 nm, 3.8 J/cm2) with 9 mW/cm2 on tissue surface. Symptom improvement and recurrence rates were assessed with a long-term follow-up from 2018 to 2021. The results were satisfactory, with significant wound size reduction, and a decrease in aspects indicative of infection including odor, presence of exudates, and purulence. After methylene blue-mediated photodynamic therapy (MB-PDT), patients showed significantly reduced wound secretion, no signs of local reaction, and no adverse effects such as burning sensation, pain, itching, skin erythema, or general malaise.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Pé Diabético Limite: Humans Idioma: En Revista: Photodiagnosis Photodyn Ther Assunto da revista: DIAGNOSTICO POR IMAGEM / TERAPEUTICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Pé Diabético Limite: Humans Idioma: En Revista: Photodiagnosis Photodyn Ther Assunto da revista: DIAGNOSTICO POR IMAGEM / TERAPEUTICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda