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Heterogeneity of HER2 Expression in Circulating Tumor Cells of Patients with Breast Cancer Brain Metastases and Impact on Brain Disease Control.
de Castro, Douglas Guedes; Pellizzon, Antônio Cássio Assis; Braun, Alexcia Camila; Chen, Michael Jenwei; Silva, Maria Letícia Gobo; Fogaroli, Ricardo Cesar; Gondim, Guilherme Rocha Melo; Ramos, Henderson; Neto, Elson Santos; Abrahão, Carolina Humeres; Yu, Liao Shin; Abdallah, Emne Ali; Calsavara, Vinicius Fernando; Chinen, Ludmilla Thomé Domingos.
Afiliação
  • de Castro DG; Department of Radiation Oncology, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
  • Pellizzon ACA; Department of Radiation Oncology, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
  • Braun AC; International Research Center, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
  • Chen MJ; Department of Radiation Oncology, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
  • Silva MLG; Department of Radiation Oncology, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
  • Fogaroli RC; Department of Radiation Oncology, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
  • Gondim GRM; Department of Radiation Oncology, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
  • Ramos H; Department of Radiation Oncology, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
  • Neto ES; Department of Radiation Oncology, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
  • Abrahão CH; Department of Radiation Oncology, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
  • Yu LS; Department of Imaging, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
  • Abdallah EA; International Research Center, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
  • Calsavara VF; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Chinen LTD; Translational Medicine Laboratory, IBCC Oncology, São Paulo 03102-002, Brazil.
Cancers (Basel) ; 14(13)2022 Jun 24.
Article em En | MEDLINE | ID: mdl-35804873
HER2 expression switching in circulating tumor cells (CTC) in breast cancer is dynamic and may have prognostic and predictive clinical implications. In this study, we evaluated the association between the expression of HER2 in the CTC of patients with breast cancer brain metastases (BCBM) and brain disease control. An exploratory analysis of a prospective assessment of CTC before (CTC1) and after (CTC2) stereotactic radiotherapy/radiosurgery (SRT) for BCBM in 39 women was performed. Distant brain failure-free survival (DBFFS), the primary endpoint, and overall survival (OS) were estimated. After a median follow-up of 16.6 months, there were 15 patients with distant brain failure and 16 deaths. The median DBFFS and OS were 15.3 and 19.5 months, respectively. The median DBFFS was 10 months in patients without HER2 expressed in CTC and was not reached in patients with HER2 in CTC (p = 0.012). The median OS was 17 months in patients without HER2 in CTC and was not reached in patients with HER2 in CTC (p = 0.104). On the multivariate analysis, DBFFS was superior in patients who were primary immunophenotype (PIP) HER2-positive (HR 0.128, 95% CI 0.025-0.534; p = 0.013). The expression of HER2 in CTC was associated with a longer DBFFS, and the switching of HER2 expression between the PIP and CTC may have an impact on prognosis and treatment selection for BCBM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cancers (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cancers (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça