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Retinal arterial occlusive vasculitis following IgA nephropathy: A case report.
Miguel, Vazquez-Membrillo; Felipe, Ramírez-Solís; Claudia, Zepeda-Palacio; Anurag, Shrivastava; Kira, Lin; Marlon, Garcia-Roa; Veronica, Romero-Morales; Yolanda, Villalpando-Gomez; Sonia, Corredor-Casas.
Afiliação
  • Miguel VM; Retina and Vitreous Department, Instituto Mexicano de Oftalmologia (IMO), Queretaro, Mexico.
  • Felipe RS; Retina and Vitreous Department, Instituto Mexicano de Oftalmologia (IMO), Queretaro, Mexico.
  • Claudia ZP; Retina and Vitreous Department, Instituto Mexicano de Oftalmologia (IMO), Queretaro, Mexico.
  • Anurag S; Department of Ophthalmology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Kira L; Department of Ophthalmology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Marlon GR; Retina and Vitreous Department, Instituto Mexicano de Oftalmologia (IMO), Queretaro, Mexico.
  • Veronica RM; Retina and Vitreous Department, Instituto Mexicano de Oftalmologia (IMO), Queretaro, Mexico.
  • Yolanda VG; Retina and Vitreous Department, Instituto Mexicano de Oftalmologia (IMO), Queretaro, Mexico.
  • Sonia CC; Head of Pathology Department, Instituto Mexicano de Oftalmologia (IMO), Queretaro, Mexico.
Eur J Ophthalmol ; 33(4): NP75-NP79, 2023 Jul.
Article em En | MEDLINE | ID: mdl-35791520
PURPOSE: To discuss diagnosis and management in the case of a patient presenting with bilateral ischemic retinal vasculopathy associated with a previously undiagnosed IgA nephropathy. CASE REPORT: In 2021, a 35-year-old male presented with a sudden onset asymmetric bilateral (OU) visual loss. Best-corrected visual acuity (BCVA) was 20/200 OD, and no light perception (NLP) OS with an associated relative afferent pupillary defect (RAPD). Slit-lamp examination (SLE) confirmed normal anterior segment anatomy OU. Indirect ophthalmoscopy and subsequent fluorescein angiography (FA) confirmed the presence of bilateral arterial attenuation, telangiectatic lesions, associated perivascular sheathing, and capillary leakage. Spectral domain optical coherence tomography (OCT) showed multiple areas of thinning of the inner retina. This constellation of diagnostic findings was highly suggestive of a bilateral ischemic retinal vasculopathy with an inflammatory vasculitis. Based on a high index of suspicion for a systemic etiology, nephrology was consulted, and a diagnosis of IgA nephropathy was confirmed by renal biopsy. Systemic immunomodulatory therapy was initiated. CONCLUSION: Although it is among the most commonly occurring forms of glomerulonephritis leading to renal failure, IgA nephropathy rarely presents with a bilateral retinal vasculopathy. Schölein - Henoch purpura, the other primary disease associated with glomerular IgA deposition, may be indistinguishable from primary IgA nephropathy. A comprehensive retinal examination with multimodal functional and structural ophthalmic diagnostic testing in conjunction with renal biopsy was needed to confirm the diagnosis. It is critical to include primary renal pathology when formulating a differential diagnosis for cases of bilateral retinal vasculitis, particularly in young otherwise healthy patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasculite Retiniana / Glomerulonefrite por IGA Limite: Adult / Humans / Male Idioma: En Revista: Eur J Ophthalmol Assunto da revista: OFTALMOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasculite Retiniana / Glomerulonefrite por IGA Limite: Adult / Humans / Male Idioma: En Revista: Eur J Ophthalmol Assunto da revista: OFTALMOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos