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Regeneration of periodontal bone defects with mesenchymal stem cells in animal models. Systematic review and meta-analysis.
Chauca-Bajaña, Luis; Velasquez-Ron, Byron; Tomás-Carmona, Inmaculada; Camacho-Alonso, Fabio; Pérez-Jardón, Alba; Pérez-Sayáns, Mario.
Afiliação
  • Chauca-Bajaña L; Faculty of Medicine and Dentistry, Oral Medicine, Oral Surgery and Implantology Unit, Periodontics and Implantology Oral Research, College Dentistry, Universidad de Guayaquil, Guayaquil, Ecuador.
  • Velasquez-Ron B; Dental Prosthesis Department Research, College Dentistry, University of the Americas, UDLA. Av, Colon y 6 de diciembre, Campus Colón, Quito, Ecuador.
  • Tomás-Carmona I; Oral Sciences Research Group, Department of Surgery and Medical-Surgical Specialties, School of Medicine and Dentistry, University of Santiago de Compostela, Health Research Institute of Santiago (IDIS), Santiago de Compostela, Spain.
  • Camacho-Alonso F; Department of Oral Surgery, University of Murcia, Murcia, Spain.
  • Pérez-Jardón A; Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes), Faculty of Medicine and Dentistry, Universidade de Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS), (ORALRES GROUP), Santiago de Compostela, A Coruña, Spain.
  • Pérez-Sayáns M; Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes), Faculty of Medicine and Dentistry, Universidade de Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS), (ORALRES GROUP), Santiago de Compostela, A Coruña, Spain. mario.perez@usc.es.
Odontology ; 111(1): 105-122, 2023 Jan.
Article em En | MEDLINE | ID: mdl-35788845
The aim of this study was to evaluate the efficacy of mesenchymal stem cells (MSCs) in the regeneration of periodontal bone defects in animal models. A systematic review and meta-analysis were conducted following the PRISMA guidelines, and the study was recorded in PROSPERO under reference number CDR42021247462. The PICO question was: is periodontal regeneration (cementum, periodontal ligament and alveolar bone) with MSCs more effective than other techniques? Three groups were considered: Group 1: MSCs alone or mixed with regenerative materials. Group 2: only regenerative materials. Group 3: no regenerative material nor MSCs. The search was conducted using MeSH with a total of 18 articles for qualitative analysis and 5 for quantitative analysis. For the meta-analysis, a modification of the effect size algorithm was developed, which considered a comparison of means between treatments using the Student's t sample distribution. When comparing the effect size between Group 1 and Group 2, the effect size for the new cementum was 2.83 mm with an estimated confidence interval of 95% (CI 95%) between 0.48 and 5.17 mm. When considering the fit to a random-effects model, the combined variance (τ2) was 6.1573 mm, with a standard deviation (SD) of 5.6008 mm and a percentage of total heterogeneity I2 of 92.33% (p < 0.0001). For new bone, the effect size was 0.88 mm, CI 95% - 0.25 to 2.01 mm, τ2 = 1.3108 mm (SD = 1.2021 mm) and I2 = 80.46%, p = 0.0004). With regard to the new periodontal ligament, it was not possible for the meta-analysis to be performed. MSCs have a greater capacity for tissue regeneration in root cementum than in alveolar bone compared to other regenerative materials.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Perda do Osso Alveolar / Células-Tronco Mesenquimais Tipo de estudo: Guideline / Qualitative_research / Systematic_reviews Limite: Animals Idioma: En Revista: Odontology Assunto da revista: ODONTOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Equador País de publicação: Japão
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Perda do Osso Alveolar / Células-Tronco Mesenquimais Tipo de estudo: Guideline / Qualitative_research / Systematic_reviews Limite: Animals Idioma: En Revista: Odontology Assunto da revista: ODONTOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Equador País de publicação: Japão